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FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.

Abstract : We investigated the effects of the sphingolipid FTY720 on tumor necrosis factor-alpha (TNF-alpha)-induced proliferation and signal transduction in human smooth muscle cells (SMC). We showed that clinically relevant concentrations of FTY720 inhibited TNF-alpha-induced SMC proliferation and extracellular signal-regulated kinase (ERK) phosphorylation. We concluded that FTY720 may be a useful drug to inhibit chronic vascular rejection.
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https://www.hal.inserm.fr/inserm-00410378
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, August 20, 2009 - 11:11:17 AM
Last modification on : Friday, January 10, 2020 - 9:09:09 PM

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Tomsen Böhler, Nassim Kamar, L. Etienne, Sylvain Galvani, Cindy Canivet, et al.. FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.. Transplantation Proceedings, Elsevier, 2009, 41 (2), pp.705-6. ⟨10.1016/j.transproceed.2008.12.017⟩. ⟨inserm-00410378⟩

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