FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells. - Archive ouverte HAL Access content directly
Journal Articles Transplantation Proceedings Year : 2009

FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.

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Abstract

We investigated the effects of the sphingolipid FTY720 on tumor necrosis factor-alpha (TNF-alpha)-induced proliferation and signal transduction in human smooth muscle cells (SMC). We showed that clinically relevant concentrations of FTY720 inhibited TNF-alpha-induced SMC proliferation and extracellular signal-regulated kinase (ERK) phosphorylation. We concluded that FTY720 may be a useful drug to inhibit chronic vascular rejection.
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inserm-00410378 , version 1 (20-08-2009)

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Tomsen Böhler, Nassim Kamar, Lucien Etienne, Sylvain Galvani, Cindy Canivet, et al.. FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.. Transplantation Proceedings, 2009, 41 (2), pp.705-6. ⟨10.1016/j.transproceed.2008.12.017⟩. ⟨inserm-00410378⟩
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