A prospective multicentre study on sural nerve action potentials in ALS.

Kirsten Pugdahl 1 Anders Fuglsang-Frederiksen 1, * Birger Johnsen 1 Mamede De Carvalho 2 Peter Fawcett 3 Annick Labarre-Vila 4 Rocco Liguori 5 Wilfred Nix 6 Ian Schofield 3
* Auteur correspondant
1 Department of Clinical Neurophysiology
2 Department of Neurology
3 Department of Clinical Neurophysiology
4 Laboratoire d'électromyographie
5 Department of Neurological Sciences
6 Department of Neurology
Abstract : OBJECTIVE: To evaluate sensory nerve conduction studies in ALS in a prospective multicentre study involving 7 neurophysiologists from 6 European countries. METHODS: Bilateral sural potentials were obtained in 35 ALS patients and 35 age-matched controls according to a standardised examination protocol using antidromic surface technique. The recordings from the right sural nerve of the controls were used for reference values. A reduction from the mean of controls greater than 2 SDs was considered abnormal. RESULTS: Reduced sensory nerve action potential (SNAP) amplitude or reduced conduction velocity (CV), or both, was found in 6 ALS patients (17%). Decrease in CV was the most frequent finding, and was observed in 8 nerves from 5 patients. Reduced SNAP amplitude was found in 2 nerves from 2 patients. All changes were minor ranging from -2.1 to -3.2 SDs. CONCLUSIONS: This is the first standardised multicentre study on sensory potentials in ALS. It confirms that although normal sensory findings should be expected in the majority of ALS patients, minor abnormalities are not uncommon. SIGNIFICANCE: Mild sensory abnormalities do not necessarily exclude a diagnosis of ALS.
Type de document :
Article dans une revue
Clinical Neurophysiology, Elsevier, 2008, 119 (5), pp.1106-10. 〈10.1016/j.clinph.2008.01.010〉
Liste complète des métadonnées

Littérature citée [34 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00410309
Contributeur : Nathalie Roux-Buisson <>
Soumis le : vendredi 19 février 2010 - 12:58:29
Dernière modification le : jeudi 11 janvier 2018 - 02:37:15
Document(s) archivé(s) le : mercredi 30 novembre 2016 - 09:54:28

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

U836

Citation

Kirsten Pugdahl, Anders Fuglsang-Frederiksen, Birger Johnsen, Mamede De Carvalho, Peter Fawcett, et al.. A prospective multicentre study on sural nerve action potentials in ALS.. Clinical Neurophysiology, Elsevier, 2008, 119 (5), pp.1106-10. 〈10.1016/j.clinph.2008.01.010〉. 〈inserm-00410309〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

329

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD