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Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.

D. L. A. Rakotondramanana 1 Mélanie Delomenède 1 Michel Baltas 1, * Hubert Duran 1 Florence Bedos-Belval 1 Philippe Rasoanaivo 2 Anne Nègre-Salvayre 3 Heinz Gornitzka 4
* Corresponding author
1 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique
2 Laboratoire de Pharmacognosie Appliquée aux Maladies Infectieuses et Parasitaires
3 Régulations cellulaires: lipidoses et atherosclerose
4 LHFA - Laboratoire Hétérochimie Fondamentale et Appliquée
Abstract : Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.
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https://www.hal.inserm.fr/inserm-00409724
Contributor : Marie Francoise Simon <>
Submitted on : Wednesday, August 12, 2009 - 3:11:03 PM
Last modification on : Monday, March 23, 2020 - 9:06:11 AM

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D. L. A. Rakotondramanana, Mélanie Delomenède, Michel Baltas, Hubert Duran, Florence Bedos-Belval, et al.. Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.. Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 (18), pp.6018-26. ⟨10.1016/j.bmc.2007.06.047⟩. ⟨inserm-00409724⟩

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