Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Proteome Research Année : 2007

Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.

Résumé

Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further encourage interest in and discussion of clinically relevant biomarker research. We express our view on proteomics for biomarker discovery by addressing multiple relevant issues, including the inherent differences between biological fluids (and how these differences affect current analytical approaches) and experimental design to maximize the efficiency of moving from the bench to the bedside. Herein, we also include suggestions for definition of the term "biomarker", based on the use of a set of universal characterization/validation requirements, and illustrate several recent examples of successful transitions of benchtop proteomic studies work to clinical practice.
Fichier non déposé

Dates et versions

inserm-00409636 , version 1 (11-08-2009)

Identifiants

Citer

David M. Good, Visith Thongboonkerd, Jan Novak, Jean-Loup Bascands, Joost P. Schanstra, et al.. Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.. Journal of Proteome Research, 2007, 6 (12), pp.4549-55. ⟨10.1021/pr070529w⟩. ⟨inserm-00409636⟩
32 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More