Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.

David Good; Visith Thongboonkerd; Jan Novak; Jean-Loup Bascands; Joost Schanstra; Joshua Coon; Anna Dominiczak; Harald Mischak

doi:10.1021/pr070529w

Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.

David Good ¹ Visith Thongboonkerd ² Jan Novak ³ Jean-Loup Bascands ⁴ Joost Schanstra ⁴ Joshua Coon ^{1, 5} Anna Dominiczak ⁶ Harald Mischak ^{7, *}

* Auteur correspondant

1 Department of Chemistry

2 Medical Molecular Biology Unit

3 Department of Microbiology

4 I2MR - Institut de médecine moléculaire de Rangueil

5 Department of Biomolecular Chemistry

6 BHF Glasgow Cardiovascular Research Centre

7 GmbH - Mosaiques Diagnostics

Abstract : Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further encourage interest in and discussion of clinically relevant biomarker research. We express our view on proteomics for biomarker discovery by addressing multiple relevant issues, including the inherent differences between biological fluids (and how these differences affect current analytical approaches) and experimental design to maximize the efficiency of moving from the bench to the bedside. Herein, we also include suggestions for definition of the term "biomarker", based on the use of a set of universal characterization/validation requirements, and illustrate several recent examples of successful transitions of benchtop proteomic studies work to clinical practice.

Type de document :

Article dans une revue

Journal of Proteome Research, American Chemical Society, 2007, 6 (12), pp.4549-55. 〈10.1021/pr070529w〉

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http://www.hal.inserm.fr/inserm-00409636
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Soumis le : mardi 11 août 2009 - 11:11:39
Dernière modification le : jeudi 13 septembre 2018 - 10:26:05

Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.

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Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.

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