FXR-deficiency confers increased susceptibility to torpor. - Archive ouverte HAL Access content directly
Journal Articles FEBS Letters Year : 2007

FXR-deficiency confers increased susceptibility to torpor.

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Abstract

The role of the nuclear receptor FXR in adaptive thermogenesis was investigated using FXR-deficient mice. Despite elevated serum bile acid concentrations and increased mRNA expression profiles of thermogenic genes in brown adipose tissue, FXR-deficiency did not alter energy expenditure under basal conditions. However, FXR-deficiency accelerated the fasting-induced entry into torpor in a leptin-dependent manner. FXR-deficient mice were also extremely cold-intolerant. These altered responses may be linked to a more rapid decrease in plasma concentrations of metabolic fuels (glucose, triglycerides) thus impairing uncoupling protein 1-driven thermogenesis. These results identify FXR as a modulator of energy homeostasis.

Dates and versions

inserm-00409558 , version 1 (10-08-2009)

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Bertrand Cariou, Emmanuel Bouchaert, Mouaadh Abdelkarim, Julie Dumont, Sandrine Caron, et al.. FXR-deficiency confers increased susceptibility to torpor.. FEBS Letters, 2007, 581 (27), pp.5191-8. ⟨10.1016/j.febslet.2007.09.064⟩. ⟨inserm-00409558⟩
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