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The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes.

Abstract : By using pangenomic microarray, we identified apelin as a unique adipokine up regulated by the transcriptional co-activator peroxisome proliferator-activated receptor gamma (PPARgamma) co-activator 1alpha (PGC-1alpha) in human white adipocytes. We investigated its regulation in vitro and in vivo. Overexpression of PGC-1alpha by adenovirus in human adipocytes induces apelin expression and secretion. Pharmacological induction of cAMP, an upstream regulator of endogenous PGC-1alpha expression, up regulates apelin gene expression and also apelin secretion in human and mice adipocytes. Moreover, during cold exposure in mice, a physiological situation known to induce both cAMP and PGC-1alpha, apelin expression in adipocytes and plasma levels were increased. This is the first demonstration that PGC-1alpha is involved in the regulation of an adipokine gene expression and release.
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https://www.hal.inserm.fr/inserm-00409175
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, August 6, 2009 - 1:41:09 PM
Last modification on : Friday, January 10, 2020 - 9:09:41 PM

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Anne Mazzucotelli, Carole Ribet, Isabelle Castan-Laurell, Danièle Daviaud, Charlotte Guigné, et al.. The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes.. Regulatory Peptides, Elsevier, 2008, 150 (1-3), pp.33-7. ⟨10.1016/j.regpep.2008.04.003⟩. ⟨inserm-00409175⟩

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