The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes.

Anne Mazzucotelli 1, * Carole Ribet 1 Isabelle Castan-Laurell 1 Danièle Daviaud 1 Charlotte Guigné 1 Dominique Langin 1, 2 Philippe Valet 1
* Auteur correspondant
1 I2MR - Institut de médecine moléculaire de Rangueil
2 Laboratoire de Biochimie [Purpan]
Abstract : By using pangenomic microarray, we identified apelin as a unique adipokine up regulated by the transcriptional co-activator peroxisome proliferator-activated receptor gamma (PPARgamma) co-activator 1alpha (PGC-1alpha) in human white adipocytes. We investigated its regulation in vitro and in vivo. Overexpression of PGC-1alpha by adenovirus in human adipocytes induces apelin expression and secretion. Pharmacological induction of cAMP, an upstream regulator of endogenous PGC-1alpha expression, up regulates apelin gene expression and also apelin secretion in human and mice adipocytes. Moreover, during cold exposure in mice, a physiological situation known to induce both cAMP and PGC-1alpha, apelin expression in adipocytes and plasma levels were increased. This is the first demonstration that PGC-1alpha is involved in the regulation of an adipokine gene expression and release.
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Article dans une revue
Regulatory Peptides, Elsevier, 2008, 150 (1-3), pp.33-7. 〈10.1016/j.regpep.2008.04.003〉
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http://www.hal.inserm.fr/inserm-00409175
Contributeur : Marie Francoise Simon <>
Soumis le : jeudi 6 août 2009 - 13:41:09
Dernière modification le : jeudi 13 septembre 2018 - 10:26:05

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Anne Mazzucotelli, Carole Ribet, Isabelle Castan-Laurell, Danièle Daviaud, Charlotte Guigné, et al.. The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes.. Regulatory Peptides, Elsevier, 2008, 150 (1-3), pp.33-7. 〈10.1016/j.regpep.2008.04.003〉. 〈inserm-00409175〉

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