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Journal articles
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar
1, 2, *
Janick Selves
3
Jean-Michel Mansuy
4
Leila Ouezzani
1
Jean-Marie Péron
2, 5
Joëlle Guitard
1
Olivier Cointault
1
Laure Esposito
1
Florence Abravanel
4, 6
Marie Danjoux
3
D. Durand
1
Jean-Pierre Vinel
5
Jacques Izopet
4, 6
Lionel Rostaing
1, 6
*
Corresponding author
Nassim Kamar 1, 2
Correspondent author
Janick Selves 3
Author
Jean-Michel Mansuy 4
Author
Leila Ouezzani 1
Author
Jean-Marie Péron 2, 5
Author
Joëlle Guitard 1
Author
Olivier Cointault 1
Author
Laure Esposito 1
Author
Jacques Izopet 4, 6
Author
Lionel Rostaing 1, 6
Author
1
Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital de Rangueil (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
2
I2MR - Institut de médecine moléculaire de Rangueil (Institut Louis Bugnard 1, avenue Jean Poulhes BP 84225 31432 TOULOUSE CEDEX 4 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- IFR150 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U858 (101, rue de Tolbiac, 75013 Paris - France)
3
Service d'anatomie pathologique et histologie-cytologie [Rangueil] (1, avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse cedex 9 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital de Rangueil (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
4
Laboratoire de Virologie [Toulouse] (330 avenue de Grande Bretagne 31059 Toulouse Cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
5
Service de Gastro-entérologie - Hépatologie [Purpan] (Place du Docteur Baylac - TSA 40031 - 31059 Toulouse cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital Purpan [Toulouse] (Place du Docteur Baylac
TSA 40031
31059 Toulouse cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
6
CPTP - Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (Hôpital de Purpan Place du Docteur Baylac 31024 TOULOUSE CEDEX 3 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1043 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5282 (France)
Abstract : Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
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Journal articles
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https://www.hal.inserm.fr/inserm-00409083
Contributor : Marie Francoise Simon <>
Submitted on : Wednesday, August 5, 2009 - 3:51:00 PM
Last modification on : Tuesday, February 18, 2020 - 3:32:02 PM
Contributor : Marie Francoise Simon <>
Submitted on : Wednesday, August 5, 2009 - 3:51:00 PM
Last modification on : Tuesday, February 18, 2020 - 3:32:02 PM
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- HAL Id : inserm-00409083, version 1
- DOI : 10.1056/NEJMoa0706992
- PUBMED : 18287603
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Citation
Nassim Kamar, Janick Selves, Jean-Michel Mansuy, Leila Ouezzani, Jean-Marie Péron, et al.. Hepatitis E virus and chronic hepatitis in organ-transplant recipients.. New England Journal of Medicine, Massachusetts Medical Society, 2008, 358 (8), pp.811-7. ⟨10.1056/NEJMoa0706992⟩. ⟨inserm-00409083⟩
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