Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar
(1, 2)
,
Janick Selves
(3)
,
Jean-Michel Mansuy
(4)
,
Leila Ouezzani
(1)
,
Jean-Marie Péron
(2, 5)
,
Joëlle Guitard
(1)
,
Olivier Cointault
(1)
,
Laure Esposito
(1)
,
Florence Legrand-Abravanel
(4, 6)
,
Marie Danjoux
(3)
,
D. Durand
(1)
,
Jean-Pierre Vinel
(5)
,
Jacques Izopet
(4, 6)
,
Lionel Rostaing
(1, 6)
1
Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation
2 I2MR - Institut de médecine moléculaire de Rangueil
3 Service d'anatomie pathologique et histologie-cytologie [Rangueil]
4 Laboratoire Virologie [CHU Toulouse]
5 Pôle Maladies de l'appareil digestif [CHU Toulouse]
6 CPTP - Centre de Physiopathologie Toulouse Purpan
2 I2MR - Institut de médecine moléculaire de Rangueil
3 Service d'anatomie pathologique et histologie-cytologie [Rangueil]
4 Laboratoire Virologie [CHU Toulouse]
5 Pôle Maladies de l'appareil digestif [CHU Toulouse]
6 CPTP - Centre de Physiopathologie Toulouse Purpan
Nassim Kamar
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- Function : Correspondent author
- PersonId : 862464
- ORCID : 0000-0003-1930-8964
- IdRef : 067702414
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Jacques Izopet
- Function : Author
- PersonId : 857751
- ORCID : 0000-0002-8462-3234
- IdRef : 058353887
Lionel Rostaing
- Function : Author
- PersonId : 862455
- ORCID : 0000-0002-5130-7286
- IdRef : 058653562
Abstract
Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.