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Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis.

Abstract : Oxidized low-density lipoprotein (oxLDL)-induced apoptosis of vascular cells may participate to plaque instability and rupture. Caveolin-1 has emerged as an important regulator of several signal transduction pathways and processes that play a role in atherosclerosis. In this study we examined the potential role of caveolin-1 in the regulation of oxLDL-induced Ca(2+) signaling and apoptosis in vascular smooth muscle cells (VSMC). Cells expressing caveolin-1 were more susceptible to oxLDL-induced apoptosis, and this was correlated with enhanced Ca(2+) entry and pro-apoptotic events. Moreover, caveolin-1 silencing by small interfering RNA decreased the level of apoptotic cells after oxLDL treatment. These findings provide new insights about the potential role of caveolin-1 in the regulation of oxLDL-induced apoptosis in vascular cells and its contribution to the instability of the plaque.
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https://www.hal.inserm.fr/inserm-00409071
Contributor : Marie Francoise Simon <>
Submitted on : Wednesday, August 5, 2009 - 2:25:48 PM
Last modification on : Friday, January 10, 2020 - 9:09:08 PM

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Cécile Ingueneau, Uyen Huynh-Do, Jean-Claude Thiers, Anne Nègre-Salvayre, Robert Salvayre, et al.. Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis.. Biochemical and Biophysical Research Communications, Elsevier, 2008, 369 (3), pp.889-93. ⟨10.1016/j.bbrc.2008.02.134⟩. ⟨inserm-00409071⟩

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