Changes in sleep-wake cycle after chronic exposure to uranium in rats.

Philippe Lestaevel 1, * Cyrill Bussy 1 François Paquet 1 Bernadette Dhieux 1 Didier Clarençon 2 Pascale Houpert 1 Patrick Gourmelon 3
* Auteur correspondant
1 Laboratoire de radiotoxicologie expérimentale, Direction de la radioprotection de l'homme
2 ANTE-INSERM U836, équipe 8, Stress et interactions neurodigestives
Unité de neuroradiobiologie
3 Direction de la radioprotection de l'homme
Abstract : Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l(-1) in drinking water, for 90 days) on electroencephalographic architecture has been studied on freely moving rats using a telemetry technique. The main effects of uranium on the sleep-wake cycle were an increase in rapid eye movement sleep (REM-sleep) and theta band power during the light period, as early as Day 30 after exposure commenced. The most probable explanation for these effects is that uranium directly affects the brain. This increase in REM-sleep was previously described in human depression or models of chronically stressed rats and it may be assimilated with some protective or compensatory mechanisms.
Type de document :
Article dans une revue
Neurotoxicology and Teratology, Elsevier, 2005, 27 (6), pp.835-40. 〈10.1016/j.ntt.2005.07.005〉
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Soumis le : mardi 14 février 2012 - 11:43:37
Dernière modification le : mercredi 29 novembre 2017 - 09:50:33
Document(s) archivé(s) le : mardi 13 décembre 2016 - 17:56:52

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Philippe Lestaevel, Cyrill Bussy, François Paquet, Bernadette Dhieux, Didier Clarençon, et al.. Changes in sleep-wake cycle after chronic exposure to uranium in rats.. Neurotoxicology and Teratology, Elsevier, 2005, 27 (6), pp.835-40. 〈10.1016/j.ntt.2005.07.005〉. 〈inserm-00407753〉

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