Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma.

Bogdan Grigoriu 1, 2, * Bachar Chahine 3 Farid Zerimech 4 Marc Grégoire 5 Malika Balduyck 4, 6 Marie-Christine Copin 7 Patrick Devos 8 Philippe Lassalle 1 Arnaud Scherpereel 1, 3
* Auteur correspondant
1 Biomolécules et inflammation pulmonaire
2 Department of Pulmonary Diseases
3 Service de pneumologie et oncologie thoraciqCHRUue
4 Service de Biochimie
5 Recherches en cancérologie
6 Laboratoire de biochimie et biologie moléculaire
7 Département de Pathologie
8 Département de biostatistiques
Abstract : We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin. MATERIALS AND METHOD: We measured serum and pleural fluid values of mesothelin and hyaluronic acid in 76 patients with MPM, 33 patients with pleural metastases of carcinomas (Mets group) and 27 patients with benign pleural effusion related to asbestos exposure (BPLAE). RESULTS: Using a serum HA cut-off of 100 microg/L, 8 patients/33 (24.2%) were positive in the Mets group versus 20/76 (26.3%) in the MPM group and only 1/27 BPLAE patients. The area under ROC curve for serum HA in MPM versus Mets or BPLAE groups was only 0.617 while it was 0.755 for mesothelin. In pleural fluid, both markers had similar diagnostic values. CONCLUSIONS: Serum mesothelin is more sensitive than hyaluronic acid in diagnosing MPM and there is no benefit in combining both markers.
Keywords : Diagnosis hyaluronic acid marker mesothelin mesothelioma pleural effusion
Type de document :
Article dans une revue
Clinical Biochemistry, Elsevier, 2009, 42 (10-11), pp.1046-50. 〈10.1016/j.clinbiochem.2009.03.007〉
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http://www.hal.inserm.fr/inserm-00407520
Contributeur : Bogdan-Dragos Grigoriu <>
Soumis le : samedi 25 juillet 2009 - 08:36:30
Dernière modification le : lundi 8 octobre 2018 - 17:44:04
Document(s) archivé(s) le : mardi 15 juin 2010 - 21:18:54

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Bogdan Grigoriu, Bachar Chahine, Farid Zerimech, Marc Grégoire, Malika Balduyck, et al.. Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma.. Clinical Biochemistry, Elsevier, 2009, 42 (10-11), pp.1046-50. 〈10.1016/j.clinbiochem.2009.03.007〉. 〈inserm-00407520〉

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