Skip to Main content Skip to Navigation
Journal articles

Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed.

Abstract : Histiocytic sarcoma (HS) refers to a highly aggressive and frequently disseminated neoplastic disease belonging to the class of canine histiocytic proliferative disorders. Disseminated HS (previously called malignant histiocytosis) is highly breed specific, with Bernese mountain dogs (BMDs), rottweilers, and retrievers having a high prevalence with a frequency of approximately 25% in the BMD breed. We collected DNA samples and clinical information from 800 BMDs, of which 200 are affected by HS. To better characterize the physiopathology and epidemiology, an in-depth analysis of 89 BMD cases has been performed. The mean age of onset was 6.5 years, males and females being equally affected. The clinical features, biochemical parameters, and pathological features have been determined. The life span after diagnosis has been estimated to be 49 days. A large BMD pedigree of 327 dogs, 121 of which are affected, was assembled. Using a subset of 160 BMDs, encompassing 21 complete sibships, we now propose an oligogenic transmission mode of the disease. Whole-genome linkage scans as well as association studies using a case/control analysis, in parallel with expression profiling of neoplastic versus normal histiocytes, are all underway. Altogether, these complementary approaches are expected to localize the genes for HS in the BMD, leading to advances in our knowledge of histiocyte diseases in dogs and humans.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00405708
Contributor : Hervé de Villemeur <>
Submitted on : Monday, July 20, 2009 - 5:57:29 PM
Last modification on : Wednesday, September 16, 2020 - 4:51:27 PM

Links full text

Identifiers

Citation

Jérôme Abadie, Benoît Hédan, Edouard Cadieu, Clotilde de Brito, Patrick Devauchelle, et al.. Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed.. The Journal of Heredity, 2009, 100 Suppl 1, pp.S19-27. ⟨10.1093/jhered/esp039⟩. ⟨inserm-00405708⟩

Share

Metrics

Record views

602