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Insights into Ca(2+) homeostasis of advanced prostate cancer cells.

Abstract : Prostate cancer is the second cancer-related cause of death. Nowadays, the aim of treatments is to decrease the effects of androgens on this organ. Unfortunately, over time, patients develop an androgen-independent cancer with a fatal outcome. The main features of late stage prostate cancer are an increased cell proliferation and apoptosis resistance. It is well known that calcium (Ca(2+)), a ubiquitous secondary messenger, is involved in several processes such as apoptosis and proliferation. In this mini review, we will focus on the changes in Ca(2+) homeostasis of prostate cancer epithelial cells during prostate cancer evolution.
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Submitted on : Tuesday, July 7, 2009 - 7:02:30 PM
Last modification on : Thursday, January 20, 2022 - 9:56:02 AM
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Matthieu Flourakis, Natacha Prevarskaya. Insights into Ca(2+) homeostasis of advanced prostate cancer cells.. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 2009, 1793 (6), pp.1105-9. ⟨10.1016/j.bbamcr.2009.01.009⟩. ⟨inserm-00402642⟩



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