Multistage designs in the genomic era: providing balance in complex disease studies.

Marie-Pierre Dubé 1 Silke Schmidt 2 Elizabeth Hauser 2, * Hatef Darabi Jing Li Amina Barhdadi Xuexia Wang Quiying Sha Zhaogong Zhang Tao Wang Hugues Aschard 3 Mickael Guedj Rori Rohlfs Amy Anderson Chelsea Taylor Lucia Mirea Radoslav Nickolov Valentin Milanov Hsin-Chao Yang Yeunjoo Song Ritwik Sinha
* Auteur correspondant
1 Department of Statistical Genetics
2 Department of Medicine
3 Méthodologie statistique et épidémiologie génétique de maladies multifactorielles
Abstract : In this summary paper, we describe the contributions included in the Multistage Design group (Group 14) at the Genetic Analysis Workshop 15, which was held during November 12-14, 2006. Our group contrasted and compared different approaches to reducing complexity in a genetic study through implementation of staged designs. Most groups used the simulated dataset (problem 3), which provided ample opportunities for evaluating various staged designs. A wide range of multistage designs that targeted different aspects of complexity were explored. We categorized these approaches as reducing phenotypic complexity, model complexity, analytic complexity or genetic complexity. In general we learned that: (1) when staged designs are carefully planned and implemented, the power loss compared to a single-stage analysis can be minimized and study cost is greatly reduced; (2) a joint analysis of the results from each stage is generally more powerful than treating the second stage as a replication analysis.
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Genetic Epidemiology, Wiley, 2007, 31 Suppl 1, pp.S118-23. 〈10.1002/gepi.20288〉
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http://www.hal.inserm.fr/inserm-00399067
Contributeur : Aschard Hugues <>
Soumis le : jeudi 25 juin 2009 - 15:48:12
Dernière modification le : jeudi 9 février 2017 - 15:50:45

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Marie-Pierre Dubé, Silke Schmidt, Elizabeth Hauser, Hatef Darabi, Jing Li, et al.. Multistage designs in the genomic era: providing balance in complex disease studies.. Genetic Epidemiology, Wiley, 2007, 31 Suppl 1, pp.S118-23. 〈10.1002/gepi.20288〉. 〈inserm-00399067〉

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