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Journal Articles Trends in Cardiovascular Medicine Year : 2006

Angiogenesis: the VE-cadherin switch.

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Abstract

Because angiogenesis is a key step in a number of pathologic processes, including tumor growth and atherosclerosis, many research studies have investigated the regulatory signals active at various stages of vascular invasion. The differential activities of the endothelial junction protein vascular endothelial (VE)-cadherin reflect the versatile behavior of endothelial cells between vascular quiescence and angiogenesis. VE-cadherin function and signaling are deeply modified in proliferating cells, and this conversion is accompanied by phosphorylation of the protein on tyrosine residues and enhanced transcription of its gene. Recent advances in the complex interplay between protein tyrosine kinases and phosphatases regulating VE-cadherin phosphorylation and function are discussed in this review.
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Origin : Files produced by the author(s)
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inserm-00398930 , version 1 (25-06-2009)

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Yann Wallez, Isabelle Vilgrain, Philippe Huber. Angiogenesis: the VE-cadherin switch.. Trends in Cardiovascular Medicine, 2006, 16 (2), pp.55-9. ⟨10.1016/j.tcm.2005.11.008⟩. ⟨inserm-00398930⟩

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