De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat. - Archive ouverte HAL Access content directly
Journal Articles Neurobiology of Disease Year : 2009

De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat.

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Abstract

We compared for the first time the effects of de novo versus long-term l-Dopa treatment inducing abnormal involuntary movement on striatal gene profiles and related bio-associations in the 6-hydroxydopamine rat model of Parkinson's disease. We examined the pattern of striatal messenger RNA expression over 4854 genes in hemiparkinsonian rats treated acutely or chronically with l-Dopa, and subsequently verified some of the gene alterations by in situ hybridization or real-time quantitative PCR. We found that de novo and long-term l-Dopa share common gene regulation features involving phosphorylation, signal transduction, secretion, transcription, translation, homeostasis, exocytosis and synaptic transmission processes. We also found that the transcriptomic response is enhanced by long-term l-Dopa and that specific biological alterations are underlying abnormal motor behavior. Processes such as growth, synaptogenesis, neurogenesis and cell proliferation may be particularly relevant to the long-term action of l-Dopa.
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Dates and versions

inserm-00398614 , version 1 (24-06-2009)

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Michèle El Atifi-Borel, Virginie Buggia-Prevot, Nadine Platet, Alim-Louis Benabid, François R. Berger, et al.. De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat.. Neurobiology of Disease, 2009, 34 (2), pp.340-50. ⟨10.1016/j.nbd.2009.02.002⟩. ⟨inserm-00398614⟩
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