Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk: Results from a multi-centre case-control study in Europe.

Adrian Cassidy 1, 2 Jessica Balsan 3 Aurélien Vesin 3 Xifeng Wu 2 Triantafillos Liloglou 1 Christian Brambilla 4 Jean-François Timsit 5 John Field 1 Euelc Consortium
1 Roy Castle Lung Cancer Research Programme
2 Department of Epidemiology
3 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
4 INSERM U823, équipe 2 (Bases Moléculaires de la Progression des Cancers du Poumon)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
5 INSERM U823, équipe 11 (Epidémiologie des cancers et des affections graves)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
Abstract : Because aggregation of cancers at different sites can occur in families, cancer could be considered as a broad phenotype with shared genetic factors. Here, we report results from a multi-centre case-control study of non-small cell lung cancer (NSCLC), with particular emphasis on a history of cancer in first-degree relatives and the risk of lung cancer. From 2002 to 2006, 733 NSCLC patients treated surgically were recruited in 8 European countries and matched to 1312 controls, by centre, sex and age. We used multivariate conditional logistic regression models to test the association between a history of cancer in first-degree relatives and risk of NSCLC. A family history of lung cancer was associated with an odds ratio (OR) for early-onset (54years or younger) NSCLC of 4.72 (95% confidence interval [CI]=1.02-21.90). A family history of gastric cancer was associated with an OR for NSCLC of 1.82 (95% CI=1.08-3.06) and for late-onset (55years or older) NSCLC of 2.92 (95% CI=1.10-7.75). Our findings provide further evidence of a familial predisposition to lung cancer and support the hypothesis that family history is a significant risk factor for the disease. Because of the inherent potential for bias in familial case-control study design, cautious interpretation is warranted.
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Article dans une revue
European Journal of Cancer, Elsevier, 2009, epub ahead of print. 〈10.1016/j.ejca.2009.05.006〉
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http://www.hal.inserm.fr/inserm-00397723
Contributeur : Aurélien Vesin <>
Soumis le : mardi 23 juin 2009 - 10:01:49
Dernière modification le : lundi 15 janvier 2018 - 11:43:26

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Adrian Cassidy, Jessica Balsan, Aurélien Vesin, Xifeng Wu, Triantafillos Liloglou, et al.. Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk: Results from a multi-centre case-control study in Europe.. European Journal of Cancer, Elsevier, 2009, epub ahead of print. 〈10.1016/j.ejca.2009.05.006〉. 〈inserm-00397723〉

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