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Gene regulation by voltage-dependent calcium channels.

Abstract : Ca(2+) is the most widely used second messenger in cell biology and fulfills a plethora of essential cell functions. One of the most exciting findings of the last decades was the involvement of Ca(2+) in the regulation of long-term cell adaptation through its ability to control gene expression. This finding provided a link between cell excitation and gene expression. In this review, we chose to focus on the role of voltage-dependent calcium channels in mediating gene expression in response to membrane depolarization. We illustrate the different pathways by which these channels are involved in excitation-transcription coupling, including the most recent Ca(2+) ion-independent strategies that highlight the transcription factor role of calcium channels.
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Contributor : Marco Canepari <>
Submitted on : Wednesday, June 10, 2009 - 4:41:01 PM
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Maud Barbado, Katell Fablet, Michel Ronjat, Michel de Waard. Gene regulation by voltage-dependent calcium channels.. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 2009, 1793 (6), pp.1096-104. ⟨10.1016/j.bbamcr.2009.02.004⟩. ⟨inserm-00394164⟩



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