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Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients.: Idiopathic hypersomnia

Abstract : OBJECTIVE: To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography. SETTING: University Hospital. DESIGN: Controlled, prospective cohort. PARTICIPANTS: 75 consecutive patients (aged 34 +/- 12 y) with idiopathic hypersomnia and 30 healthy matched controls. INTERVENTION: Patients and controls underwent during 48 hours a face-to-face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h ad libitum sleep monitoring. RESULTS: Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493-558 min in controls, versus 672-718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 +/- 10 vs 40 +/- 13 y, P = 0.0002), slimmer (body mass index: 26 +/- 5 vs 23 +/- 4 kg/m2; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal (> 8 min) in 71% hypersomniacs with long sleep time. CONCLUSIONS: Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.
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https://www.hal.inserm.fr/inserm-00392758
Contributor : Isabelle Arnulf <>
Submitted on : Tuesday, December 15, 2009 - 3:51:00 PM
Last modification on : Thursday, March 21, 2019 - 12:27:49 PM
Long-term archiving on: : Thursday, June 10, 2010 - 10:21:44 PM

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  • HAL Id : inserm-00392758, version 1
  • PUBMED : 19544751

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Cyrille Vernet, Isabelle Arnulf. Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients.: Idiopathic hypersomnia. SLEEP, American Academy of Sleep Medicine, 2009, 32 (6), pp.753-9. ⟨inserm-00392758⟩

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