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A Hybrid Tissue-Level Model of the Left Ventricle: Application to the Analysis of the Regional Cardiac Function in Heart Failure

Abstract : This work contributes to the systemic interpretation of clinical data for the analysis of the regional cardiac function in the context of heart failure. A two-step patient-specific approach, combining a realistic geometry and a hybrid, tissue-level electromechanical model of the left ventricle is proposed. For the first step, a fast framework to extract a realistic geometry of the left ventricle from MSCT data is proposed. This geometry is then applied to a tissue-level model of the left ventricle, coupling a discrete electrical model, a mechanical model integrating a visco-elastic law, solved by a finite element method and a hydraulic model. A set of simulations carried out with the model are shown and preliminary results of the parameter identification approach, based on real patient data, are presented and discussed.
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https://www.hal.inserm.fr/inserm-00392548
Contributor : Lotfi Senhadji <>
Submitted on : Tuesday, June 9, 2009 - 8:27:15 AM
Last modification on : Thursday, March 5, 2020 - 6:38:55 PM
Long-term archiving on: : Friday, June 11, 2010 - 12:28:33 AM

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Julien Fleureau, Mireille Garreau, Erwan Donal, Christophe Leclercq, Alfredo Hernandez. A Hybrid Tissue-Level Model of the Left Ventricle: Application to the Analysis of the Regional Cardiac Function in Heart Failure. Functional Imaging and Modeling of the Heart, Jun 2009, Nice, France. pp.258-267, ⟨10.1007/978-3-642-01932-6_28⟩. ⟨inserm-00392548⟩

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