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No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study.

Abstract : OBJECTIVE: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. DESIGN: Multicentre prospective intervention study, randomized, double-blind, placebo-control. SETTING: France (Clermont-Ferrand/Theix, and Grenoble), Italy (Rome), Northern Ireland (Coleraine). SUBJECTS: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. METHODS: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. RESULTS: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly, after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. CONCLUSIONS: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.
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https://www.hal.inserm.fr/inserm-00392288
Contributor : Sarah Hamant <>
Submitted on : Saturday, June 6, 2009 - 3:40:42 PM
Last modification on : Wednesday, July 15, 2020 - 9:10:04 AM

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  • HAL Id : inserm-00392288, version 1
  • PRODINRA : 226112
  • PUBMED : 18978165
  • WOS : 000260934500004

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Maud Andriollo-Sanchez, Isabelle Hininger-Favier, Nathalie Meunier, Eugenia Venneria, Jacqueline M O'Connor, et al.. No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study.. Journal of the American College of Nutrition, Taylor & Francis (Routledge): STM, Behavioural Science and Public Health Titles, 2008, 27 (4), pp.463-9. ⟨inserm-00392288⟩

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