Cardiac mechanoenergetics in silico. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Neuro endocrinology letters Année : 2002

Cardiac mechanoenergetics in silico.

Résumé

The aim of this thesis is to investigate the link between biochemical intracellular processes and mechanical contraction of the cardiac muscle. First, the regulation of intracellular energy fluxes between mitochondria and myofibrils is studied. It is shown, that the experimentally observed metabolic stability of the cardiac muscle is reproducible by a simple feedback regulation mechanism, i.e., ATP consumption in myofibrils and ATP production in mitochondria are balanced by the changes of the high energy phosphate concentrations. Second, an important property of energy transformation from biochemical form to mechanical work in the cardiac muscle, the linear relationship between the oxygen consumption and the stress-strain area, is replicated by a cross-bridge model. Third, by using the developed cross-bridge model, the correlation between ejection fraction of the left ventricle and heterogeneity of sarcomere strain, developed stress and ATP consumption in the left ventricular wall is established. Fourth, an experimentally observed linear relationship between oxygen consumption and the pressure-volume area can be predicted theoretically from a linear relationship between the oxygen consumption and the stress-strain area. Summing up, it is shown how the macrovariables of a cardiac muscle are interwoven with intracellular physiological processes into a whole.
Fichier non déposé

Dates et versions

inserm-00392264 , version 1 (06-06-2009)

Identifiants

  • HAL Id : inserm-00392264 , version 1
  • PUBMED : 11880857

Citer

Marko Vendelin, Peter H M Bovendeerd, Valdur A Saks, Jüri Engelbrecht. Cardiac mechanoenergetics in silico.. Neuro endocrinology letters, 2002, 23 (1), pp.13-20. ⟨inserm-00392264⟩

Collections

INSERM UGA
53 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More