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Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions.

Abstract : Most memory CD8 T cell subsets that have been hitherto defined are generated in response to infectious pathogens. In this study, we have characterized the CD8 T cells that survive priming conditions, devoid of pathogen-derived danger signals. In both a TCR-transgenic model and a model of contact hypersensitivity, we show that the priming of naive CD8 T cells under sterile inflammatory conditions generates memory. The corresponding memory CD8 T cells can be identified by their intermediate expression levels of CD44 and CD122. We also show that CD44/122(int) memory CD8 T cells spontaneously develop in wild type mice and that they display intermediate levels of several other memory traits including functional (IFN-gamma secretion capacity, CCL5 messenger stores), phenotypic, and molecular (T-bet and eomesodermin expression levels) features. We finally show that they correspond to an early differentiation stage and can further differentiate in CD44/122(high) memory T cells. Altogether, our results identify a new memory CD8 T cell subset that is generated under sterile inflammatory conditions and involved in the recall contact hypersensitivity reactions that are responsible for allergic contact dermatitis.
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Contributor : Alexandra Fargeot <>
Submitted on : Friday, June 5, 2009 - 12:10:26 PM
Last modification on : Tuesday, November 19, 2019 - 2:37:35 AM

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Florentin Martial Mbitikon-Kobo, Marc Vocanson, Marie-Cécile Michallet, Martine Tomkowiak, Anne Cottalorda, et al.. Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (6), pp.3846-54. ⟨10.4049/jimmunol.0802438⟩. ⟨inserm-00392005⟩



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