Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease. - Archive ouverte HAL Access content directly
Journal Articles Journal of Neuropsychiatry Year : 2006

Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease.

(1) , (1) , (1) , (1) , (1) , (2) , (3) , (1) , (4)
1
2
3
4

Abstract

Patients with Parkinson's disease frequently have mild to moderate depression and exhibit low hedonic tone. The authors investigate the impact of a single L-dopa challenge and the acute effects of electric stimulation of the subthalamic nucleus (STN) on symptoms of depression and hedonic tone. Depressive symptoms improved with L-dopa and STN stimulation to the same extent. However, hedonic tone improved only with L-dopa. Most of the emotional changes did not correlate with changes in motor performance, indicating they were not just reactive but specific to the treatment. These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge.
Not file

Dates and versions

inserm-00391637 , version 1 (04-06-2009)

Identifiers

Cite

Karsten Witt, Christine Daniels, Jan Herzog, Delia Lorenz, Jens Volkmann, et al.. Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease.. Journal of Neuropsychiatry, 2006, 18 (3), pp.397-401. ⟨10.1176/appi.neuropsych.18.3.397⟩. ⟨inserm-00391637⟩

Collections

INSERM UGA
181 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More