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Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease.

Abstract : Patients with Parkinson's disease frequently have mild to moderate depression and exhibit low hedonic tone. The authors investigate the impact of a single L-dopa challenge and the acute effects of electric stimulation of the subthalamic nucleus (STN) on symptoms of depression and hedonic tone. Depressive symptoms improved with L-dopa and STN stimulation to the same extent. However, hedonic tone improved only with L-dopa. Most of the emotional changes did not correlate with changes in motor performance, indicating they were not just reactive but specific to the treatment. These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge.
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https://www.hal.inserm.fr/inserm-00391637
Contributor : Marc Savasta <>
Submitted on : Thursday, June 4, 2009 - 12:08:44 PM
Last modification on : Thursday, June 11, 2009 - 3:28:08 PM

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Karsten Witt, Christine Daniels, Jan Herzog, Delia Lorenz, Jens Volkmann, et al.. Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease.. Journal of Neuropsychiatry, 2006, 18 (3), pp.397-401. ⟨10.1176/appi.neuropsych.18.3.397⟩. ⟨inserm-00391637⟩

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