The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2006

The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.

Résumé

The Homer family of scaffold proteins couples NMDA receptors to metabotropic glutamate receptors and links extracellular signals to calcium release from intracellular stores. Ania-3 is a member of the Homer family and is rapidly inducible in brain in response to diverse stimuli. Here, we report the identification of the plasma membrane Ca2+ ATPase (PMCA) as a novel Ania-3/Homer-associated protein. Ania-3/Homer interacts with the b-splice forms of all PMCAs (PMCA1b, 2b, 3b, and 4b) via their PDZ domain-binding COOH-terminal tail. Ectopically expressed Ania-3 colocalized with the PMCA at the plasma membrane of polarized MDCK epithelial cells, and endogenous Ania-3/Homer and PMCA2 are co-expressed in the soma and dendrites of primary rat hippocampal neurons. The interaction between Ania-3/Homer and PMCAs may represent a novel mechanism by which local calcium signaling and hence synaptic function can be modulated in neurons.

Dates et versions

inserm-00391633 , version 1 (04-06-2009)

Identifiants

Citer

Véronique Sgambato-Faure, Yuning Xiong, Joshua D. Berke, Steven E. Hyman, Emanuel E. Strehler. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.. Biochemical and Biophysical Research Communications, 2006, 343 (2), pp.630-7. ⟨10.1016/j.bbrc.2006.03.020⟩. ⟨inserm-00391633⟩

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