Skip to Main content Skip to Navigation
Journal articles

Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells.

Abstract : In this short review, the merits and limits of three theoretical concepts explaining the functional role of the creatine kinase system in muscle and brain cells are analysed. In addition to the usual concept of an energy buffer system and the recently proposed metabolic capacity theory (Sweeney, H.L. (1994) Med. Sci. Sports Exerc. 26, 30-36), it is proposed that coupled creatine kinase systems are involved in effective metabolic regulation of energy fluxes and oxidative phosphorylation, beside their energy transfer function. This aspect of the system is considered on the basis of metabolic control analysis. It is shown by using the results of mathematical modelling that, due to amplification of ADP fluxes from the cytoplasm by the mechanism of metabolic channelling, coupled mitochondrial creatine kinase may exert a flux control coefficient significantly exceeding 1.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00391366
Contributor : Sarah Hamant <>
Submitted on : Wednesday, June 3, 2009 - 5:53:45 PM
Last modification on : Thursday, November 19, 2020 - 3:52:36 PM

Identifiers

  • HAL Id : inserm-00391366, version 1
  • PUBMED : 8664307

Collections

LBFA | UGA

Citation

Valdur Saks, Renée Ventura-Clapier, Mayis Aliev. Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells.. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 1996, 1274 (3), pp.81-8. ⟨inserm-00391366⟩

Share

Metrics

Record views

631