Skip to Main content Skip to Navigation
Journal articles

The interaction between magnetization transfer and blood-oxygen-level-dependent effects.

Abstract : Low-power off-resonance spin-echo magnetization transfer (MT) imaging experiments with a long repetition time (TR) were performed on rat brain for a range of arterial PCO2 levels. The measured magnetization transfer ratio decreased with increased arterial PCO2 levels. When performing blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI)-type data analysis in which signal intensities were normalized to the normocapnic state, the CO2-based BOLD effect was much stronger with than without saturation. This increased effect is a consequence of the fact that the MT effect reduces the signal intensity in tissue more than in blood, thereby amplifying the contribution of the intravascular BOLD signal change to the overall BOLD effect. The results offer a potential approach to measure absolute cerebral blood volume in vivo and to amplify the BOLD effects for fMRI studies.
Document type :
Journal articles
Complete list of metadata
Contributor : Michel Dojat Connect in order to contact the contributor
Submitted on : Thursday, June 9, 2011 - 9:54:13 PM
Last modification on : Friday, November 6, 2020 - 4:02:06 AM
Long-term archiving on: : Friday, December 2, 2016 - 8:43:15 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Jinyuan Zhou, Jean-Francois Payen, Peter C. M. van Zijl. The interaction between magnetization transfer and blood-oxygen-level-dependent effects.. Magnetic Resonance in Medicine, Wiley, 2005, 53 (2), pp.356-66. ⟨10.1002/mrm.20348⟩. ⟨inserm-00391194⟩



Record views