Skip to Main content Skip to Navigation
Journal articles

Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.

Abstract : Although oral administration of L-Dopa remains the best therapy for Parkinson disease, its long-term administration causes the appearance of abnormal involuntary movements such as dyskinesia. Although persistent striatal induction of some genes has already been associated with such pathologic profiles in hemiparkinsonian rats, molecular and cellular mechanisms underlying such long-term adaptations remain to be elucidated. In this study, using a rat model of L-Dopa-induced dyskinesia, we report that activity regulated cytoskeletal (Arc)-associated protein is strongly upregulated in the lesioned striatum and that the extent of its induction further varies according to the occurrence or absence of locomotor sensitization. Moreover, Arc is preferentially induced, along with FosB, nur77, and homer-1a, in striatonigral neurons, which express mRNA encoding the precursor of dynorphin. Given the likely importance of Arc in the regulation of cytoskeleton during synaptic plasticity, its upregulation supports the hypothesis that a relationship exists between cytoskeletal modifications and the longlasting action of chronically administrated L-Dopa.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00391107
Contributor : Jean-Paul Issartel <>
Submitted on : Wednesday, June 3, 2009 - 2:51:39 PM
Last modification on : Friday, November 6, 2020 - 4:07:49 AM

Identifiers

  • HAL Id : inserm-00391107, version 1
  • PUBMED : 16254488

Collections

UGA

Citation

Véronique Sgambato-Faure, Virginie Buggia, François Gilbert, Daniel Lévesque, Alim-Louis Benabid, et al.. Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.. Journal of Neuropathology and Experimental Neurology, Lippincott, Williams & Wilkins, 2005, 64 (11), pp.936-47. ⟨inserm-00391107⟩

Share

Metrics

Record views

110