Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures. - Archive ouverte HAL Access content directly
Journal Articles Brain Research Year : 2007

Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures.

, , (1) , , , , ,
1
Angélique D. Ducray
  • Function : Author
Rachel Qualls
  • Function : Author
Robert H. Andres
  • Function : Author
Ekkehard Dreher
  • Function : Author
Rolf W. Seiler
  • Function : Author
Théo Wallimann
  • Function : Author
Hans Rudolf Widmer
  • Function : Author

Abstract

In the present study, we investigated the expression pattern of cytosolic brain specific-BB-CK and ubiquitous mitochondrial-creatine kinases (uMt-CK) in developing human spinal cord. Consequently, we studied the effects of creatine treatment on cultured fetal human spinal cord tissue. We found that both CK isoforms were expressed in fetal spinal cord at all time points investigated (5 to 11.5 weeks post conception) and correspondingly specific CK activity was detected. Chronic creatine exposure resulted in significantly higher densities of GABA-immunoreactive neurons in the cultures, while total neuronal cell density was not altered, suggesting a differentiation inducing mechanism of creatine supplementation. Taken together, our observations favour the view that the creatine phosphocreatine system plays an important role in the developing CNS.

Dates and versions

inserm-00390893 , version 1 (03-06-2009)

Identifiers

Cite

Angélique D. Ducray, Rachel Qualls, Uwe Schlattner, Robert H. Andres, Ekkehard Dreher, et al.. Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures.. Brain Research, 2007, 1137 (1), pp.50-7. ⟨10.1016/j.brainres.2006.12.038⟩. ⟨inserm-00390893⟩

Collections

INSERM UGA LBFA
126 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More