Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Molecular and Cellular Neuroscience Year : 2006

Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.

Abstract

Amyloid precursor protein (APP) is involved in the pathogenesis of Alzheimer's disease (AD). However, the physiological role of APP and its family members is still unclear. To gain insights into APP function, we used a proteomic approach to identify APP interacting proteins. We report here for the first time a direct interaction between the C-terminal region of APP family proteins and ubiquitous mitochondrial creatine kinase (uMtCK). This interaction was confirmed in vitro as well as in cultured cells and in brain. Interestingly, expression of full-length and C-terminal domain of APP family proteins stabilized uMtCK preprotein in cultured cells. Our data suggest that APP may regulate cellular energy levels and mitochondrial function via a direct interaction and stabilization of uMtCK.

Dates and versions

inserm-00390877 , version 1 (02-06-2009)

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Xiaofan Li, Tanja Bürklen, Xianglin Yuan, Uwe Schlattner, Dominic M. Desiderio, et al.. Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.. Molecular and Cellular Neuroscience, 2006, 31 (2), pp.263-72. ⟨10.1016/j.mcn.2005.09.015⟩. ⟨inserm-00390877⟩

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