Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach. - Archive ouverte HAL Access content directly
Journal Articles Molecular and Cellular Biochemistry Year : 1998

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.

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Abstract

Mitochondrial creatine kinase (Mi-CK) is a central enzyme in energy metabolism of tissues with high and fluctuating energy requirements. In this review, recent progress in the functional and structural characterization of Mi-CK is summarized with special emphasis on the solved X-ray structure of chicken Mib-CK octamer (Fritz-Wolf et al., Nature 381, 341-345, 1996). The new results are discussed in a historical context and related to the characteristics of CK isoforms as known from a large number of biophysical and biochemical studies. Finally, two hypothetical functional aspects of the Mi-CK structure are proposed: (i) putative membrane binding motifs at the top and bottom faces of the octamer and (ii) a possible functional role of the central 20 A channel.
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Dates and versions

inserm-00390791 , version 1 (02-06-2009)

Identifiers

  • HAL Id : inserm-00390791 , version 1
  • PUBMED : 9746317

Cite

Uwe Schlattner, Michael Forstner, Eder Eder, Olaf Stachowiak, Karin Fritz-Wolf, et al.. Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.. Molecular and Cellular Biochemistry, 1998, 184 (1-2), pp.125-40. ⟨inserm-00390791⟩

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