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Journal articles
Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.
Abstract : Mitochondrial creatine kinase (Mi-CK) is a central enzyme in energy metabolism of tissues with high and fluctuating energy requirements. In this review, recent progress in the functional and structural characterization of Mi-CK is summarized with special emphasis on the solved X-ray structure of chicken Mib-CK octamer (Fritz-Wolf et al., Nature 381, 341-345, 1996). The new results are discussed in a historical context and related to the characteristics of CK isoforms as known from a large number of biophysical and biochemical studies. Finally, two hypothetical functional aspects of the Mi-CK structure are proposed: (i) putative membrane binding motifs at the top and bottom faces of the octamer and (ii) a possible functional role of the central 20 A channel.
https://www.hal.inserm.fr/inserm-00390791
Contributor : Sarah Hamant <>
Submitted on : Tuesday, June 2, 2009 - 5:49:28 PM
Last modification on : Tuesday, March 5, 2019 - 9:30:10 AM
Contributor : Sarah Hamant <>
Submitted on : Tuesday, June 2, 2009 - 5:49:28 PM
Last modification on : Tuesday, March 5, 2019 - 9:30:10 AM