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N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.

Abstract : N(6)-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction-modification systems. Certain groups of Proteobacteria also harbour solitary DNA adenine methyltransferases that provide signals for DNA-protein interactions. In gamma-proteobacteria, Dam methylation regulates chromosome replication, nucleoid segregation, DNA repair, transposition of insertion elements and transcription of specific genes. In Salmonella, Haemophilus, Yersinia and Vibrio species and in pathogenic Escherichia coli, Dam methylation is required for virulence. In alpha-proteobacteria, CcrM methylation regulates the cell cycle in Caulobacter, Rhizobium and Agrobacterium, and has a role in Brucella abortus infection.
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https://www.hal.inserm.fr/inserm-00390766
Contributor : Jean-Paul Issartel <>
Submitted on : Friday, July 31, 2009 - 9:04:29 AM
Last modification on : Thursday, August 6, 2009 - 11:47:56 AM
Long-term archiving on: : Friday, June 11, 2010 - 12:13:25 AM

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Didier Wion, Josep Casadesús. N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.. Nature Reviews Microbiology, Nature Publishing Group, 2006, 4 (3), pp.183-92. ⟨10.1038/nrmicro1350⟩. ⟨inserm-00390766⟩

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