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Journal articles
Cortical folding in patients with bipolar disorder or unipolar depression.
Jani Penttilä
1, *
Marie-Laure Paillère-Martinot
1, 2
Jean-Luc Martinot
1
Damien Ringuenet
1, 3
Michèle Wessa
1, 4
Josselin Houenou
1, 5
Thierry Gallarda
6
Frank Bellivier
5, 7
André Galinowski
6, 8
Pascale Bruguière
9, 10
François Pinabel
11
Marion Leboyer
5, 7
Jean-Pierre Olié
6, 8
Edouard Duchesnay
1, 12
Eric Artiges
1
Jean-François Mangin
1, 12
Arnaud Cachia
1
*
Corresponding author
Jani Penttilä 1
Correspondent author
Marie-Laure Paillère-Martinot 1, 2
Author
Jean-Luc Martinot 1
Author
Damien Ringuenet 1, 3
Author
Michèle Wessa 1, 4
Author
Josselin Houenou 1, 5
Author
Thierry Gallarda 6
Author
Frank Bellivier 5, 7
Author
André Galinowski 6, 8
Author
Pascale Bruguière 9, 10
Author
François Pinabel 11
Author
Marion Leboyer 5, 7
Author
Jean-Pierre Olié 6, 8
Author
Edouard Duchesnay 1, 12
Author
Eric Artiges 1
Author
Jean-François Mangin 1, 12
Author IdHAL : jean-francois-mangin ORCID : https://orcid.org/0000-0002-1612-461X
Arnaud Cachia 1
Author IdHAL : arnaud-cachia ORCID : https://orcid.org/0000-0003-2125-4985
1
Imagerie Cerebrale en Psychiatrie (Cea 4, Place du General Leclerc 91401 ORSAY CEDEX - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DSV/I2BM (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U797 (101, rue de Tolbiac, 75013 Paris - France)
2
la maison des adolescents (27, rue du Fbg Saint-Jacques 75679 Paris cedex 14 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Cochin [AP-HP] (27 Rue du Faubourg Saint-Jacques 75014 Paris - France)
3
Département de psychiatrie et addictologie (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Paul Brousse (12 Avenue Paul Vaillant Couturier, 94800 Villejuif - France)
4
Department of Cognitive and Clinical Neuroscience (Central Institute of Mental Health, Mannheim - Germany)
- Universität Heidelberg [Heidelberg] ( Seminarstraße 2, 69117 Heidelberg - Germany)
5
Service de psychiatrie (Créteil - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Henri Mondor (France)
- Hôpital Albert Chenevier (France)
7
IMRB - Institut Mondor de Recherche Biomédicale (8 rue du Général Sarrail 94010 Créteil - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U955 (101, rue de Tolbiac, 75013 Paris - France)
- IFR10 (France)
- UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12 : UMR955 (61 avenue du Général de Gaulle - 94010 Créteil cedex - France)
8
U894 / UMS 1266 - Institut de psychiatrie et neurosciences (Centre de Psychiatrie et Neurosciences - Inserm U894
102-108 Rue de la Santé
75014 PARIS - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMS 1266 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMS_S 894 (101, rue de Tolbiac, 75013 Paris - France)
9
Physiologie et physiopathologie de la motricité chez l'homme (GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- IFR70 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U731 (101, rue de Tolbiac, 75013 Paris - France)
10
Service de médecine physique et de réadaptation [CHU Pitié-Salpêtrière] (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
11
Service de psychiatrie [Le Kremlin-Bicêtre] (78, avenue du Général Leclerc – 94270 Le Kremlin-Bicêtre - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Bicêtre (France)
12
LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur (France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DSV/I2BM/NEUROSPIN (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
Abstract : BACKGROUND: Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding. METHODS: We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for anatomic deviations in patients with bipolar disorder (16 patients with treatment-resistant depression, 25 with euthymia) and unipolar depression (35 patients with treatment-resistant depression). RESULTS: Compared with healthy controls, both groups of patients with treatment-resistant depression exhibited reduced g-SIs: in the right hemisphere among patients with bipolar disorder and in both hemispheres among those with unipolar depression. Patients with euthymic bipolar disorder did not differ significantly from depressed patients or healthy controls. Among patients with bipolar disorder who were taking lithium, we found positive correlations between current lithium dose and g-SIs in both hemispheres. LIMITATIONS: We cannot estimate the extent to which the observed g-SI reductions are linked to treatment resistance and to what extent they are state-dependent. Furthermore, we cannot disentangle the impact of medications from that of the affective disorder. Finally, there is interindividual variation and overlap of g-SIs among patients and healthy controls that need to be considered when interpreting our results. CONCLUSION: Reduced global cortical folding surface appears to be characteristic of patients with treatment-resistant depression, either unipolar or bipolar. In patients with bipolar disorder, treatment with lithium may modify cortical folding surface.
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Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-00390374
Contributor : Georges Guellaen <>
Submitted on : Tuesday, June 2, 2009 - 8:44:18 AM
Last modification on : Thursday, December 10, 2020 - 3:42:29 AM
Long-term archiving on: : Saturday, November 26, 2016 - 10:11:48 AM
Contributor : Georges Guellaen <>
Submitted on : Tuesday, June 2, 2009 - 8:44:18 AM
Last modification on : Thursday, December 10, 2020 - 3:42:29 AM
Long-term archiving on: : Saturday, November 26, 2016 - 10:11:48 AM
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- HAL Id : inserm-00390374, version 1
- PUBMED : 19270763
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INSERM | CEA | UNIV-PARIS5 | UPMC | IMRB | UPEC | UPEC-UPEM | USPC | SORBONNE-UNIVERSITE | SU-MEDECINE | UNIV-PARIS | UP-SANTE | SU-TI
Citation
Jani Penttilä, Marie-Laure Paillère-Martinot, Jean-Luc Martinot, Damien Ringuenet, Michèle Wessa, et al.. Cortical folding in patients with bipolar disorder or unipolar depression.. Journal of Psychiatry and Neuroscience, Canadian Medical Association, 2009, 34 (2), pp.127-35. ⟨inserm-00390374⟩
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