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Cortical folding in patients with bipolar disorder or unipolar depression.

Jani Penttilä 1, * Marie-Laure Paillère-Martinot 1, 2 Jean-Luc Martinot 1 Damien Ringuenet 1, 3 Michèle Wessa 1, 4 Josselin Houenou 1, 5 Thierry Gallarda 6 Frank Bellivier 5, 7 André Galinowski 6, 8 Pascale Bruguière 9, 10 François Pinabel 11 Marion Leboyer 5, 7 Jean-Pierre Olié 6, 8 Edouard Duchesnay 1, 12 Eric Artiges 1 Jean-François Mangin 1, 12 Arnaud Cachia 1
* Corresponding author
1 Imagerie Cerebrale en Psychiatrie
2 la maison des adolescents
3 Département de psychiatrie et addictologie
4 Department of Cognitive and Clinical Neuroscience
5 Service de psychiatrie
6 Département de psychiatrie
7 IMRB - Institut Mondor de Recherche Biomédicale
8 U894 / UMS 1266 - Institut de psychiatrie et neurosciences
9 Physiologie et physiopathologie de la motricité chez l'homme
10 Service de médecine physique et de réadaptation [CHU Pitié-Salpêtrière]
11 Service de psychiatrie [Le Kremlin-Bicêtre]
12 LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur
Abstract : BACKGROUND: Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding. METHODS: We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for anatomic deviations in patients with bipolar disorder (16 patients with treatment-resistant depression, 25 with euthymia) and unipolar depression (35 patients with treatment-resistant depression). RESULTS: Compared with healthy controls, both groups of patients with treatment-resistant depression exhibited reduced g-SIs: in the right hemisphere among patients with bipolar disorder and in both hemispheres among those with unipolar depression. Patients with euthymic bipolar disorder did not differ significantly from depressed patients or healthy controls. Among patients with bipolar disorder who were taking lithium, we found positive correlations between current lithium dose and g-SIs in both hemispheres. LIMITATIONS: We cannot estimate the extent to which the observed g-SI reductions are linked to treatment resistance and to what extent they are state-dependent. Furthermore, we cannot disentangle the impact of medications from that of the affective disorder. Finally, there is interindividual variation and overlap of g-SIs among patients and healthy controls that need to be considered when interpreting our results. CONCLUSION: Reduced global cortical folding surface appears to be characteristic of patients with treatment-resistant depression, either unipolar or bipolar. In patients with bipolar disorder, treatment with lithium may modify cortical folding surface.
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https://www.hal.inserm.fr/inserm-00390374
Contributor : Georges Guellaen <>
Submitted on : Tuesday, June 2, 2009 - 8:44:18 AM
Last modification on : Wednesday, September 16, 2020 - 5:07:05 PM
Long-term archiving on: : Saturday, November 26, 2016 - 10:11:48 AM

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  • HAL Id : inserm-00390374, version 1
  • PUBMED : 19270763

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Jani Penttilä, Marie-Laure Paillère-Martinot, Jean-Luc Martinot, Damien Ringuenet, Michèle Wessa, et al.. Cortical folding in patients with bipolar disorder or unipolar depression.. Journal of Psychiatry and Neuroscience, Canadian Medical Association, 2009, 34 (2), pp.127-35. ⟨inserm-00390374⟩

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