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Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.

Abstract : The effects of almitrine on ATPase/ATPsynthase previously described in beef heart mitochondria (Rigoulet et al. (1990) Biochim. Biophys. Acta 1018, 91-97) are also observed in liver mitochondria isolated from rats older than 7 weeks. In contrast, in rats younger than 5 weeks, almitrine at the same concentration has no effect on the ATPase/ATPsynthase complex. This age-dependent action of almitrine is well correlated with age-dependent modifications of two fatty acids: linoleic and docosahexaenoic acids. The possibility of a change in H+/ATP stoichiometry of the ATPase/ATPsynthase induced by almitrine seems related to more general modifications of membrane properties during growth of the rat.
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https://www.hal.inserm.fr/inserm-00390264
Contributor : Sarah Hamant <>
Submitted on : Monday, June 1, 2009 - 2:14:44 PM
Last modification on : Friday, November 6, 2020 - 3:46:57 AM

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  • HAL Id : inserm-00390264, version 1
  • PUBMED : 8435438

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Muriel Jumelle-Laclau, Michel Rigoulet, Nicole Averet, Xavier Leverve, Lilliane Dubourg, et al.. Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 1993, 1141 (1), pp.90-4. ⟨inserm-00390264⟩

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