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Splanchnic acid-base status and urea metabolism in uremic rats.

Abstract : Acidosis may alter hepato-splanchnic amino acid metabolism during uremia.26 uremic rats and 30 controls were studied for portal and arterial acid-base balance and urea synthesis during enteral nutrition. Uremic rats exhibited increased (p < 0.05) portal H(+) (47.20 +/- 0.018 vs 43.05 +/- 0.49 nmol/I) and decreased HCO(3)(-) (19.45 +/- 0.69 vs 23.01 +/- 0.57 mmol/l) without significant change in arterial H(+) (45.29 +/- 1.13 vs 43.15 +/- 0.49) and HCO(3)(-) (18.41 +/- 0.64 vs 19.59 +/- 0.49). Porto-arterial difference showed an intestinal HCO(3)(-) release in controls only (3.53 +/- 0.64 mmol/l). Urea synthesis rate was significantly enhanced by enteral nutrition in controls only: 54.33 +/- 17.3 vs -11.8 +/- 20 micromol/min 100g body mass. Thus, during uremia, portal acidosis was associated with a decrease in enteral nutrition-induced urea synthesis.
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https://www.hal.inserm.fr/inserm-00390251
Contributor : Sarah Hamant <>
Submitted on : Monday, June 1, 2009 - 1:09:50 PM
Last modification on : Wednesday, November 7, 2018 - 4:07:41 PM

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  • HAL Id : inserm-00390251, version 1
  • PUBMED : 16843909

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Noël Cano, Xavier Leverve, Jeanne Di Costanzo-Dufetel, Robert Novaretti, Jean-Pierre Reynier. Splanchnic acid-base status and urea metabolism in uremic rats.. Clinical Nutrition, Elsevier, 1995, 14 (2), pp.116-22. ⟨inserm-00390251⟩

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