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Chronic ethanol ingestion increases efficiency of oxidative phosphorylation in rat liver mitochondria.

Abstract : The efficiency of oxidative phosphorylation was compared between rats chronically fed with ethanol and controls. (i) Results showed that the liver mitochondria state 4 respiratory rate was strongly inhibited, while the corresponding proton-motive force was not affected; (ii) the cytochrome oxidase content and activity were decreased and (iii) the oxidative-phosphorylation yield was increased in the ethanol exposed group. Furthermore, oxidative phosphorylation at coupling site II was not affected by ethanol. Cytochrome oxidase inhibition by sodium-azide mimicked the effects of ethanol intoxication in control mitochondria. This indicates that the decrease in cytochrome oxidase activity induced by ethanol intoxication directly increases the efficiency of oxidative phosphorylation.
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https://www.hal.inserm.fr/inserm-00390046
Contributor : Sarah Hamant <>
Submitted on : Saturday, June 6, 2009 - 12:17:36 PM
Last modification on : Friday, March 6, 2020 - 1:45:18 AM

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  • HAL Id : inserm-00390046, version 1
  • PUBMED : 10692594

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Marie-Astrid Piquet, Véronique Nogueira, Anne Devin, Brigitte Sibille, Céline Filippi, et al.. Chronic ethanol ingestion increases efficiency of oxidative phosphorylation in rat liver mitochondria.. FEBS Letters, Wiley, 2000, 468 (2-3), pp.239-42. ⟨inserm-00390046⟩

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