A. Artru and J. Michenfelder, Effects of Hypercarbia on Canine Cerebral Metabolism and Blood Flow with Simultaneous Direct and Indirect Measurement of Blood Flow, Anesthesiology, vol.52, issue.6, pp.466-469, 1980.
DOI : 10.1097/00000542-198006000-00002

P. A. Bandettini and E. C. Wong, A hypercapnia-based normalization method for improved spatial localization of human brain activation with fMRI, NMR in Biomedicine, vol.30, issue.4-5, pp.4-5, 1997.
DOI : 10.1002/(SICI)1099-1492(199706/08)10:4/5<197::AID-NBM466>3.0.CO;2-S

R. Banzett, H. Mulnier, K. Murphy, S. Rosen, R. Wise et al., Breathlessness in humans activates insular cortex, NeuroReport, vol.11, issue.10, pp.2117-2120, 2000.
DOI : 10.1097/00001756-200007140-00012

Y. Behzadi and T. Liu, An arteriolar compliance model of the cerebral blood flow response to neural stimulus, NeuroImage, vol.25, issue.4, pp.1100-1111, 2005.
DOI : 10.1016/j.neuroimage.2004.12.057

J. C. Bezdek, L. O. Hall, and L. P. Clarke, Review of MR image segmentation techniques using pattern recognition, Medical Physics, vol.20, issue.4, pp.1033-1048, 1993.
DOI : 10.1118/1.597000

G. Brown, L. Eyler-zorrilla, B. Georgy, S. Kindermann, E. Wong et al., BOLD and Perfusion Response to Finger-Thumb Apposition After Acetazolamide Administration: Differential Relationship to Global Perfusion, Journal of Cerebral Blood Flow & Metabolism, vol.40, issue.7, pp.829-837, 2003.
DOI : 10.1097/01.WCB.0000071887.63724.B2

H. Bruhn, A. Kleinschmidt, H. Boecker, K. Merboldt, W. Hanicke et al., The Effect of Acetazolamide on Regional Cerebral Blood Oxygenation at Rest and under Stimulation as Assessed by MRI, Journal of Cerebral Blood Flow & Metabolism, vol.33, issue.5, pp.742-748, 1994.
DOI : 10.1038/jcbfm.1992.131

H. Bruhn, P. Fransson, and J. Frahm, Modulation of cerebral blood oxygenation by indomethacin: MRI at rest and functional brain activation, Journal of Magnetic Resonance Imaging, vol.267, issue.3, pp.325-334, 2001.
DOI : 10.1002/jmri.1047

R. Buxton, A hypothesis for cerebral blood flow regulation and the origin of the BOLD effect, Proceedings of the Twelfth Annual Meeting of the ISMRM, p.273, 2004.

E. Cohen, K. Ugurbil, and S. Kim, Effect of Basal Conditions on the Magnitude and Dynamics of the Blood Oxygenation Level???Dependent fMRI Response, Journal of Cerebral Blood Flow & Metabolism, vol.14, pp.1042-1053, 2002.
DOI : 10.1097/00004647-200209000-00002

D. Corfield, K. Murphy, O. Josephs, L. Adams, and R. Turner, Does Hypercapnia-Induced Cerebral Vasodilation Modulate the Hemodynamic Response to Neural Activation?, NeuroImage, vol.13, issue.6, pp.1207-1211, 2001.
DOI : 10.1006/nimg.2001.0760

R. J. Cox, AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance Neuroimages, Computers and Biomedical Research, vol.29, issue.3, pp.162-173, 1996.
DOI : 10.1006/cbmr.1996.0014

T. Davis, K. Kwong, R. Weisskoff, and B. Rosen, Calibrated functional MRI: Mapping the dynamics of oxidative metabolism, Proceedings of the National Academy of Sciences, vol.95, issue.4, pp.1834-1839, 1998.
DOI : 10.1073/pnas.95.4.1834

K. Evans, R. Banzett, L. Adams, L. Mckay, R. Frackowiak et al., BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger, J. Neurophysiol, vol.88, issue.3, pp.1500-1511, 2002.

K. Friston, C. Frith, P. Liddle, R. Dolan, A. Lammertsma et al., The Relationship between Global and Local Changes in PET Scans, Journal of Cerebral Blood Flow & Metabolism, vol.35, issue.4, pp.458-466, 1990.
DOI : 10.1038/jcbfm.1990.88

R. Gollub, H. Breiter, H. Kantor, D. Kennedy, D. Gastfriend et al., Cocaine Decreases Cortical Cerebral Blood Flow But Does Not Obscure Regional Activation in Functional Magnetic Resonance Imaging in Human Subjects, Journal of Cerebral Blood Flow & Metabolism, vol.16, issue.7, pp.724-734, 1998.
DOI : 10.1097/00004647-199807000-00003

R. Grubb, M. Phelps, and J. Eichling, The Effects of Changes in PaCO2 Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time, Stroke, vol.5, issue.5, pp.630-639, 1974.
DOI : 10.1161/01.STR.5.5.630

R. D. Hoge, J. Atkinson, B. Gill, G. Crelier, S. Marrett et al., Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model, Magnetic Resonance in Medicine, vol.85, issue.5, pp.849-863, 1999.
DOI : 10.1002/(SICI)1522-2594(199911)42:5<849::AID-MRM4>3.0.CO;2-Z

R. D. Hoge, J. Atkinson, B. Gill, G. R. Crelier, S. Marrett et al., Additive combination of perfusion responses to hypercapnia and visual stimulation, Proceeding of the Fifth International Conference on Functional Mapping of the Human Brain, p.306, 1999.

A. Kastrup, G. Krueger, T. Neumann-haefelin, G. Glover, and M. E. Moseley, Changes of Cerebral Blood Flow, Oxygenation, and Oxidative Metabolism during Graded Motor Activation, NeuroImage, vol.15, issue.1, pp.74-82, 2002.
DOI : 10.1006/nimg.2001.0916

L. Kemna, S. Posse, L. Tellmann, T. Schmitz, and H. Herzog, Interdependence of Regional and Global Cerebral Blood Flow During Visual Stimulation: An O-15-Butanol Positron Emission Tomography Study, Journal of Cerebral Blood Flow & Metabolism, vol.21, issue.6, pp.664-670, 2001.
DOI : 10.1097/00004647-200106000-00004

P. Laurienti, A. Field, J. Burdette, J. Maldjian, Y. Yen et al., Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal, Am. J. Neuroradiol, issue.8, pp.24-1607, 2003.

T. Li, M. Moseley, and G. Glover, A FAIR Study of Motor Cortex Activation under Normo- and Hypercapnia Induced by Breath Challenge, NeuroImage, vol.10, issue.5, pp.562-569, 1999.
DOI : 10.1006/nimg.1999.0496

T. Li, A. Kastrup, M. Moseley, and G. Glover, Changes in baseline cerebral blood flow in humans do not influence regional cerebral blood flow response to photic stimulation, Journal of Magnetic Resonance Imaging, vol.10, issue.5, pp.757-762, 2000.
DOI : 10.1002/1522-2586(200011)12:5<757::AID-JMRI14>3.0.CO;2-4

T. Liu, Y. Behzadi, K. Restom, K. Uludag, K. Lu et al., Caffeine alters the temporal dynamics of the visual BOLD response, NeuroImage, vol.23, issue.4, pp.1402-1413, 2004.
DOI : 10.1016/j.neuroimage.2004.07.061

V. Maximillian, I. Prohovnik, and J. Risberg, Cerebral hemodynamic response to mental activation in normo- and hypercapnia, Stroke, vol.11, issue.4, pp.342-347, 1980.
DOI : 10.1161/01.STR.11.4.342

T. Mulderink, D. Gitelman, M. Mesulam, and T. Parrish, On the Use of Caffeine as a Contrast Booster for BOLD fMRI Studies, NeuroImage, vol.15, issue.1, pp.37-44, 2002.
DOI : 10.1006/nimg.2001.0973

S. Posse, L. Kemna, B. Elghahwagi, S. Wiese, and V. Kiselev, Effect of graded hypo- and hypercapnia on fMRI contrast in visual cortex: Quantification ofT*2 changes by multiecho EPI, Magnetic Resonance in Medicine, vol.17, issue.2, pp.264-271, 2001.
DOI : 10.1002/mrm.1187

M. Poulin, P. Liang, and P. Robbins, Dynamics of the cerebral blood flow response to step changes in end-tidal P CO 2 and P O 2 in humans, J. Appl. Physiol, vol.81, issue.3, pp.1084-1095, 1996.

W. H. Press, S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery, Numerical Recipes in C: The Art of Scientific Computing, pp.666-670, 1992.

S. Ramsay, K. Murphy, S. Shea, K. Friston, A. Lammertsma et al., Changes in global cerebral blood flow in humans: effect on regional cerebral blood flow during a neural activation task., The Journal of Physiology, vol.471, issue.1, pp.521-534, 1993.
DOI : 10.1113/jphysiol.1993.sp019913

E. Rostrup, I. Law, M. Blinkenberg, H. Larsson, A. Born et al., Regional Differences in the CBF and BOLD Responses to Hypercapnia: A Combined PET and fMRI Study, NeuroImage, vol.11, issue.2, pp.87-97, 2000.
DOI : 10.1006/nimg.1999.0526

E. Rostrup, G. Knudsen, I. Law, S. Holm, H. Larsson et al., The relationship between cerebral blood flow and volume in humans, NeuroImage, vol.24, issue.1, pp.1-11, 2005.
DOI : 10.1016/j.neuroimage.2004.09.043

E. Shimosegawa, I. Kanno, J. Hatazawa, H. Fujita, H. Ito et al., Photic Stimulation Study of Changing the Arterial Partial Pressure Level of Carbon Dioxide, Journal of Cerebral Blood Flow & Metabolism, vol.12, issue.1, pp.111-114, 1995.
DOI : 10.1002/ana.410140512

B. Stefanovic, J. Sled, and G. Pike, QuantitativeT2 in the occipital lobe: The role of the CPMG refocusing rate, Journal of Magnetic Resonance Imaging, vol.147, issue.3, pp.302-309, 2003.
DOI : 10.1002/jmri.10360

B. Stefanovic, J. M. Warnking, and G. B. Pike, Hemodynamic and metabolic responses to neuronal inhibition, NeuroImage, vol.22, issue.2, pp.771-778, 2004.
DOI : 10.1016/j.neuroimage.2004.01.036

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.420.7497

J. M. Warnking and G. B. Pike, Bandwidth-modulated adiabatic RF pulses for uniform selective saturation and inversion, Magnetic Resonance in Medicine, vol.38, issue.5, pp.1190-1199, 2004.
DOI : 10.1002/mrm.20262

M. Weckesser, S. Posse, U. Olthoff, L. Kemna, S. Dager et al., Functional imaging of the visual cortex with bold-contrast MRI: Hyperventilation decreases signal response, Magnetic Resonance in Medicine, vol.11, issue.4, pp.213-216, 1999.
DOI : 10.1002/(SICI)1522-2594(199901)41:1<213::AID-MRM31>3.0.CO;2-S

E. Wong, R. Buxton, and L. Frank, Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling, NMR in Biomedicine, vol.31, issue.4-5, pp.237-249, 1997.
DOI : 10.1002/(SICI)1099-1492(199706/08)10:4/5<237::AID-NBM475>3.0.CO;2-X

K. Worsley, C. Liao, J. Aston, V. Petre, G. Duncan et al., A General Statistical Analysis for fMRI Data, NeuroImage, vol.15, issue.1, pp.1-15, 2002.
DOI : 10.1006/nimg.2001.0933

F. Ye, J. Frank, D. Weinberger, and A. Mclaughlin, Noise reduction in 3D perfusion imaging by attenuating the static signal in arterial spin tagging (ASSIST), Magnetic Resonance in Medicine, vol.8, issue.1, pp.92-100, 2000.
DOI : 10.1002/1522-2594(200007)44:1<92::AID-MRM14>3.0.CO;2-M