Skip to Main content Skip to Navigation
Journal articles

The effect of global cerebral vasodilation on focal activation hemodynamics.

Abstract : In view of the potential of global resting blood flow level to confound the interpretation of blood oxygenation level-dependent (BOLD) fMRI studies, we investigated the effect of pronounced elevation in baseline cerebral blood flow (CBF) on BOLD and CBF responses to functional activation. Twelve healthy volunteers performed bilateral finger apposition while attending to a radial yellow/blue checkerboard. Three levels of global CBF increase were achieved by inhaling 5, 7.5 or 10% CO2. CBF and BOLD signals were simultaneously quantified using interleaved multi-slice pulsed arterial spin labeling (PASL) and T2*-weighted gradient echo sequences. Increasing basal CBF produced a significant decrease in the activation-induced BOLD response, with the slope of the optimal linear fit of activation versus basal BOLD signal changes of -0.32 +/- 0.01%/% for motor and visual cortex regions of interest (ROIs). While the modulation in basal flow level also produced a statistically significant effect on the activation-induced CBF change, the degree of relative attenuation of the flow response was slight, with a slope of -0.18 +/- 0.02%/% in the motor and -0.13 +/- 0.01%/% in the visual cortex ROI. The current findings describe a strong attenuation of the BOLD response at significantly elevated basal flow levels and call for independent quantification of resting CBF in BOLD fMRI studies that involve subjects and/or conditions with markedly elevated global perfusion.
Complete list of metadatas

Cited literature [41 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00388982
Contributor : Michel Dojat <>
Submitted on : Monday, August 17, 2009 - 3:07:11 PM
Last modification on : Thursday, June 18, 2020 - 12:32:04 PM
Long-term archiving on: : Saturday, November 26, 2016 - 9:14:47 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

U836 | UGA

Citation

Bojana Stefanovic, Jan Warnking, Karin Rylander, G Bruce Pike. The effect of global cerebral vasodilation on focal activation hemodynamics.. NeuroImage, Elsevier, 2006, 30 (3), pp.726-34. ⟨10.1016/j.neuroimage.2005.10.038⟩. ⟨inserm-00388982⟩

Share

Metrics

Record views

198