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Article Dans Une Revue Brain Research Année : 2006

Immunocytochemical analysis of rat vagus nerve by antibodies against glycogen phosphorylase isozymes.

Résumé

Glycogen is an endogenous store of glucose equivalents for energy metabolism in many tissues. The brain contains a significant amount of glycogen the role of which as an energy reserve is currently under debate. Apparently little is known concerning a possible role of glycogen in peripheral nerves. We have demonstrated immunocytochemically the presence of glycogen phosphorylase (GP), a key enzyme in glycogen metabolism, in large and small axons of the rat vagus nerve, but not in Schwann cells. Furthermore, the isozyme-specific antibodies applied detected only the presence of the brain isoform BB of GP, but not the muscle isoform MM. This is in agreement with the occurrence of solely the BB isoform in the few brain and spinal cord neurons that contain GP. In contrast, astroglial cells in brain and spinal cord have previously been shown to contain both isoforms. Since GP isozymes are regulated differentially, the expression of isoform BB may provide hints to possible functions of glycogen in the vagus nerve.

Dates et versions

inserm-00388978 , version 1 (27-05-2009)

Identifiants

Citer

Brigitte Pfeiffer-Guglielmi, Jonathan A. Coles, Mike Francke, Andreas Reichenbach, Burkhard Fleckenstein, et al.. Immunocytochemical analysis of rat vagus nerve by antibodies against glycogen phosphorylase isozymes.. Brain Research, 2006, 1110 (1), pp.23-9. ⟨10.1016/j.brainres.2006.06.080⟩. ⟨inserm-00388978⟩
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