High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma. - Archive ouverte HAL Access content directly
Journal Articles Journal of Cerebral Blood Flow and Metabolism Year : 2005

High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma.

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Abstract

The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood-brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47x47 microm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.
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inserm-00388911 , version 1 (15-10-2009)

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Jean-François Adam, Christian Nemoz, Alberto Bravin, Stefan Fiedler, Sam Bayat, et al.. High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma.. Journal of Cerebral Blood Flow and Metabolism, 2005, 25 (2), pp.145-53. ⟨10.1038/sj.jcbfm.9600017⟩. ⟨inserm-00388911⟩

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