 |
Journal articles
High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma.
Abstract : The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood-brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47x47 microm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.
Cited literature [49 references]
https://www.hal.inserm.fr/inserm-00388911
Contributor : Raphael Serduc <>
Submitted on : Thursday, October 15, 2009 - 9:32:31 AM
Last modification on : Friday, November 6, 2020 - 4:07:26 AM
Long-term archiving on: : Saturday, November 26, 2016 - 8:51:25 AM
Contributor : Raphael Serduc <>
Submitted on : Thursday, October 15, 2009 - 9:32:31 AM
Last modification on : Friday, November 6, 2020 - 4:07:26 AM
Long-term archiving on: : Saturday, November 26, 2016 - 8:51:25 AM