Skip to Main content Skip to Navigation
Journal articles

High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma.

Abstract : The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood-brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47x47 microm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.
Complete list of metadatas

Cited literature [49 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00388911
Contributor : Raphael Serduc <>
Submitted on : Thursday, October 15, 2009 - 9:32:31 AM
Last modification on : Thursday, November 28, 2019 - 3:26:02 PM
Long-term archiving on: : Saturday, November 26, 2016 - 8:51:25 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

U836 | UGA

Citation

Jean-François Adam, Christian Nemoz, Alberto Bravin, Stefan Fiedler, Sam Bayat, et al.. High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2005, 25 (2), pp.145-53. ⟨10.1038/sj.jcbfm.9600017⟩. ⟨inserm-00388911⟩

Share

Metrics

Record views

228