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Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.

Abstract : PURPOSE: Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation. METHODS AND MATERIALS: Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total). RESULTS: For doses
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Submitted on : Thursday, October 15, 2009 - 9:51:25 AM
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Jean-François Adam, Aurélie Joubert, Marie-Claude Biston, Anne-Marie Charvet, Michel Peoc'H, et al.. Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.. International Journal of Radiation Oncology - Biology - Physics, Elsevier, 2006, 64 (2), pp.603-11. ⟨10.1016/j.ijrobp.2005.09.004⟩. ⟨inserm-00388754⟩

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