Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.

Jean-François Adam; Aurélie Joubert; Marie-Claude Biston; Anne-Marie Charvet; Michel Peoc'H; Jean-François Le Bas; Jacques Balosso; François Estève; Hélène Elleaume

doi:10.1016/j.ijrobp.2005.09.004

Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.

Jean-François Adam ^{1, 2} Aurélie Joubert ^{1, 2} Marie-Claude Biston ^{1, 2} Anne-Marie Charvet ^{1, 2} Michel Peoc'H ³ Jean-François Le Bas ^{1, 4} Jacques Balosso ^{1, 5} François Estève ^{1, 2, 4} Hélène Elleaume ^{1, 2, *}

* Auteur correspondant

1 RSRM - Rayonnement Synchrotron et Recherche Medicale

2 ID17 - Biomedical Beamline

3 Département de pathologie

4 IRM - Service d'Imagerie par Résonance Magnétique

5 Département de cancérologie et d'hématologie

Abstract : PURPOSE: Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation. METHODS AND MATERIALS: Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total). RESULTS: For doses

Type de document :

Article dans une revue

International Journal of Radiation Oncology - Biology - Physics, Elsevier, 2006, 64 (2), pp.603-11. 〈10.1016/j.ijrobp.2005.09.004〉

Domaine :

Sciences du Vivant [q-bio] / Cancer

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Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.

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Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.

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