Lactate in the intensive care unit: pyromaniac, sentinel or fireman?

Abstract : Lactate, indispensable substrate of mammalian intermediary metabolism, allows shuttling of carbons and reducing power between cells and organs at a high turnover rate. Lactate is, therefore, not deleterious, although an increase in its concentration is often a sensitive sign of alteration in energy homeostasis, a rise in it being frequently related to poor prognosis. Such an increase, however, actually signifies an attempt by the body to cope with a new energy status. Hyperlactatemia, therefore, most often represents an adaptive response to an acute energy disorder. Investigation of lactate metabolism at the bedside is limited to the determination of its concentration. Lactate metabolism and acid-base homeostasis are both closely linked to cellular energy metabolism, acidosis being potentially a cause or a consequence of cellular energy deficit.
Type de document :
Article dans une revue
Critical Care, BioMed Central, 2005, 9 (6), pp.622-3. 〈10.1186/cc3935〉
Liste complète des métadonnées

https://www.hal.inserm.fr/inserm-00388724
Contributeur : Sarah Hamant <>
Soumis le : mercredi 27 mai 2009 - 11:29:54
Dernière modification le : mercredi 7 novembre 2018 - 16:07:41

Lien texte intégral

Identifiants

Collections

UGA

Citation

Xavier Leverve. Lactate in the intensive care unit: pyromaniac, sentinel or fireman?. Critical Care, BioMed Central, 2005, 9 (6), pp.622-3. 〈10.1186/cc3935〉. 〈inserm-00388724〉

Partager

Métriques

Consultations de la notice

47