Profound effects of the general anesthetic etomidate on oxidative phosphorylation without effects on their yield. - Archive ouverte HAL Access content directly
Journal Articles Journal of Bioenergetics Year : 2006

Profound effects of the general anesthetic etomidate on oxidative phosphorylation without effects on their yield.

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Abstract

We investigated the effects of the general anesthetic Etomidate on oxidative phosphorylation in isolated rat liver mitochondria. The study of each electron transfer site shows that there is an inhibition: mainly at complex I but also, to a lesser extent, at complex III. Moreover, with succinate as substrate, the increase in non-phosphorylating respiration is accompanied by a decrease in DeltaPsi. However, this effect is not due to classical uncoupling of oxidative phosphorylation, since ADP addition at high Etomidate concentrations restores the transmembrane difference of electrical potential. Also, in the same range of Etomidate concentration, the ATP/O ratio is not significantly affected. In conclusion, the main effect of Etomidate is to decrease the oxidative phosphorylation rate without changing yield. The H(+) leak which appears under non-phosphorylating conditions becomes negligible in physiological conditions.

Dates and versions

inserm-00388693 , version 1 (27-05-2009)

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Anne Devin, Véronique Nogueira, Nicole Avéret, Xavier M Leverve, Michel Rigoulet. Profound effects of the general anesthetic etomidate on oxidative phosphorylation without effects on their yield.. Journal of Bioenergetics, 2006, 38 (2), pp.137-42. ⟨10.1007/s10863-006-9013-6⟩. ⟨inserm-00388693⟩

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