O. Attree, I. M. Olivos, I. Okabe, L. C. Bailey, D. L. Nelson et al., The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase, Nature, vol.358, issue.6383, pp.239-242, 1992.
DOI : 10.1038/358239a0

J. Peck, G. T. Douglas, C. H. Wu, and P. D. Burbelo, Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships, FEBS Letters, vol.130, issue.1-3, pp.27-34, 2002.
DOI : 10.1016/S0014-5793(02)03331-8

X. Zhang, A. B. Jefferson, V. Auethavekiat, and P. W. Majerus, The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase., Proc. Natl Acad. Sci. USA, pp.4853-4856, 1995.
DOI : 10.1073/pnas.92.11.4853

S. F. Suchy, I. M. Olivos-glander, and R. L. Nussbaum, Lowe Syndrome, a deficiency of a phosphatidyl-inositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus, Human Molecular Genetics, vol.4, issue.12, pp.2245-2250, 1995.
DOI : 10.1093/hmg/4.12.2245

X. Zhang, P. A. Hartz, E. Philip, L. C. Racusen, and P. W. Majerus, Cell Lines from Kidney Proximal Tubules of a Patient with Lowe Syndrome Lack OCRL Inositol Polyphosphate 5-Phosphatase and Accumulate Phosphatidylinositol 4,5-Bisphosphate, Journal of Biological Chemistry, vol.273, issue.3, pp.1574-1582, 1998.
DOI : 10.1074/jbc.273.3.1574

M. R. Wenk, L. Lucast, D. Paolo, G. Romanelli, A. J. Suchy et al., Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry, Nature Biotechnology, vol.21, issue.7, pp.813-817, 2003.
DOI : 10.1038/nbt837

D. Raucher, T. Stauffer, W. Chen, K. Shen, S. Guo et al., Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton???Plasma Membrane Adhesion, Cell, vol.100, issue.2, pp.221-228, 2000.
DOI : 10.1016/S0092-8674(00)81560-3

B. Payrastre, K. Missy, S. Giuriato, S. Bodin, M. Plantavid et al., Phosphoinositides : key players in cell signalling, in time and space, Cellular Signalling, vol.13, issue.6, pp.377-387, 2001.
DOI : 10.1016/S0898-6568(01)00158-9

M. A. Dressman, I. M. Olivos-glander, R. L. Nussbaum, and S. F. Suchy, -Golgi Network of Fibroblasts and Epithelial Cells, Journal of Histochemistry & Cytochemistry, vol.92, issue.2, pp.179-190, 2000.
DOI : 10.1177/002215540004800203

URL : https://hal.archives-ouvertes.fr/hal-00796618

A. J. Ungewickell and P. W. Majerus, Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome, Proc. Natl Acad. Sci. USA, pp.13342-13344, 1999.
DOI : 10.1073/pnas.96.23.13342

A. Ungewickell, M. E. Ward, E. Ungewickell, and P. W. Majerus, The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin, Proc. Natl Acad. Sci. USA, pp.13501-13506, 2004.
DOI : 10.1073/pnas.0405664101

S. F. Suchy and R. L. Nussbaum, The Deficiency of PIP2 5-Phosphatase in Lowe Syndrome Affects Actin Polymerization, The American Journal of Human Genetics, vol.71, issue.6, pp.1420-1427, 2002.
DOI : 10.1086/344517

T. Lin, B. M. Orrison, S. F. Suchy, R. A. Lewis, and R. L. Nussbaum, Mutations Are Not Uniformly Distributed throughout theOCRL1Gene in Lowe Syndrome Patients, Molecular Genetics and Metabolism, vol.64, issue.1, pp.58-61, 1998.
DOI : 10.1006/mgme.1998.2687

H. M. Loovers, K. Veenstra, H. Snippe, X. Pesesse, C. Erneux et al., A Diverse Family of Inositol 5-Phosphatases Playing a Role in Growth and Development in Dictyostelium discoideum, Journal of Biological Chemistry, vol.278, issue.8, pp.5652-5658, 2003.
DOI : 10.1074/jbc.M208396200

A. Faucherre, P. Desbois, V. Satre, J. Lunardi, O. Dorseuil et al., Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network, Human Molecular Genetics, vol.12, issue.19, pp.2449-2456, 2003.
DOI : 10.1093/hmg/ddg250

L. Van-aelst, D. Souza-schorey, and C. , Rho GTPases and signaling networks, Genes & Development, vol.11, issue.18, pp.2295-2322, 1997.
DOI : 10.1101/gad.11.18.2295

S. Etienne-manneville and A. Hall, Rho GTPases in cell biology, Nature, vol.92, issue.6916, pp.629-635, 2002.
DOI : 10.1074/jbc.M108297200

Y. Takai, T. Sasaki, and T. Matozaki, Small GTP-Binding Proteins, Physiol. Rev, vol.81, pp.153-208, 2001.
DOI : 10.1016/S0074-7696(08)61861-6

A. J. Ridley, H. F. Paterson, C. L. Johnston, D. Diekmann, and A. Hall, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, vol.70, issue.3, pp.401-410, 1992.
DOI : 10.1016/0092-8674(92)90164-8

A. Hall, Rho GTPases and the Actin Cytoskeleton, Science, vol.279, issue.5350, pp.509-514, 1998.
DOI : 10.1126/science.279.5350.509

N. Monnier, V. Satre, E. Lerouge, F. Berthoin, and J. Lunardi, OCRL1 mutation analysis in French Lowe syndrome patients: Implications for molecular diagnosis strategy and genetic counseling, Human Mutation, vol.16, issue.2, pp.157-165, 2000.
DOI : 10.1002/1098-1004(200008)16:2<157::AID-HUMU8>3.0.CO;2-9

A. J. Singer and R. A. Clark, Cutaneous wound healing, N. Engl. J. Med, vol.341, pp.738-746, 1999.

W. Li, J. Fan, M. Chen, S. Guan, D. Sawcer et al., Mechanism of Human Dermal Fibroblast Migration Driven by Type I Collagen and Platelet-derived Growth Factor-BB, Molecular Biology of the Cell, vol.15, issue.1, 2004.
DOI : 10.1091/mbc.E03-05-0352

C. H. Heldin and B. Westermark, Mechanism of action and in vivo role of platelet-derived growth factor, Physiol. Rev, vol.79, pp.1283-1316, 1999.

Y. J. Wang, J. Wang, H. Q. Sun, M. Martinez, Y. X. Sun et al., Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi, Cell, vol.114, issue.3, pp.299-310, 2003.
DOI : 10.1016/S0092-8674(03)00603-2

C. Pendaries, H. Tronchere, M. Plantavid, and B. Payrastre, Phosphoinositide signaling disorders in human diseases, FEBS Letters, vol.101, issue.1, pp.25-31, 2003.
DOI : 10.1016/S0014-5793(03)00437-X

S. A. Watt, G. Kular, I. N. Fleming, C. P. Downes, and J. M. Lucocq, Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C ??1, Biochemical Journal, vol.363, issue.3, pp.657-666, 2002.
DOI : 10.1042/bj3630657

R. Gurung, A. Tan, L. M. Ooms, M. J. Mcgrath, R. D. Huysmans et al., Identification of a Novel Domain in Two Mammalian Inositol-polyphosphate 5-Phosphatases That Mediates Membrane Ruffle Localization: THE INOSITOL 5-PHOSPHATASE SKIP LOCALIZES TO THE ENDOPLASMIC RETICULUM AND TRANSLOCATES TO MEMBRANE RUFFLES FOLLOWING EPIDERMAL GROWTH FACTOR STIMULATION, Journal of Biological Chemistry, vol.278, issue.13, pp.11376-11385, 2003.
DOI : 10.1074/jbc.M209991200

T. Ijuin, Y. Mochizuki, K. Fukami, M. Funaki, T. Asano et al., Identification and Characterization of a Novel Inositol Polyphosphate 5-Phosphatase, Journal of Biological Chemistry, vol.275, issue.15, pp.10870-10875, 2000.
DOI : 10.1074/jbc.275.15.10870

R. H. Insall and O. D. Weiner, PIP3, PIP2, and Cell Movement???Similar Messages, Different Meanings?, Developmental Cell, vol.1, issue.6, pp.743-747, 2001.
DOI : 10.1016/S1534-5807(01)00086-7

URL : http://doi.org/10.1016/s1534-5807(01)00086-7

P. Hilpela, M. K. Vartiainen, and P. Lappalainen, Regulation of the Actin Cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3, Curr. Top. Microbiol. Immunol, vol.282, pp.117-163, 2004.
DOI : 10.1007/978-3-642-18805-3_5

L. Van-aelst and M. Symons, Role of Rho family GTPases in epithelial morphogenesis, Genes & Development, vol.16, issue.9, pp.1032-1054, 2002.
DOI : 10.1101/gad.978802