Skip to Main content Skip to Navigation
Journal articles

Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomized study.

Abstract : Although intradialytic parenteral nutrition (IDPN) is a method used widely to combat protein-calorie malnutrition in hemodialysis patients, its effect on survival has not been thoroughly studied. We conducted a prospective, randomized trial in which 186 malnourished hemodialysis patients received oral nutritional supplements with or without 1 year of IDPN. IDPN did not improve 2-year mortality (primary end point), hospitalization rate, Karnofsky score, body mass index, or laboratory markers of nutritional status. Instead, both groups demonstrated improvement in body mass index and the nutritional parameters serum albumin and prealbumin (P < 0.05). Multivariate analysis showed that an increase in prealbumin of >30 mg/L within 3 months, a marker of nutritional improvement, independently predicted a 54% decrease in 2-year mortality, as well as reduced hospitalizations and improved general well-being as measured by the Karnofsky score. Therefore, although we found no definite advantage of adding IDPN to oral nutritional supplementation, this is the first prospective study demonstrating that an improvement in prealbumin during nutritional therapy is associated with a decrease in morbidity and mortality in malnourished hemodialysis patients.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00388543
Contributor : Sarah Hamant <>
Submitted on : Tuesday, May 26, 2009 - 10:57:09 PM
Last modification on : Friday, November 6, 2020 - 4:07:03 AM

Links full text

Identifiers

Collections

Citation

Noël Cano, Denis Fouque, Hubert Roth, Michel Aparicio, Raymond Azar, et al.. Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomized study.. Journal of the American Society of Nephrology, American Society of Nephrology, 2007, 18 (9), pp.2583-91. ⟨10.1681/ASN.2007020184⟩. ⟨inserm-00388543⟩

Share

Metrics

Record views

317