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Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.

Abstract : OBJECTIVES: Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids, hypothermia and hypertonic saline. We investigated the effect of a new hyperosmolar solution based on sodium lactate in controlling raised intracranial pressure (ICP). DESIGN AND SETTING: Prospective open randomized study in an adult ICU. PATIENTS: Thirty-four patients with isolated severe TBI (Glasgow Coma Scale
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https://www.hal.inserm.fr/inserm-00388527
Contributor : Sarah Hamant <>
Submitted on : Tuesday, May 26, 2009 - 9:09:04 PM
Last modification on : Wednesday, July 15, 2020 - 9:10:04 AM

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Carole Ichai, Guy Armando, Jean-Christophe Orban, Fréderic Berthier, Laurent Rami, et al.. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.. Annales Françaises d'Anesthésie et de Réanimation, Elsevier Masson, 2009, 35 (3), pp.471-9. ⟨10.1007/s00134-008-1283-5⟩. ⟨inserm-00388527⟩

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