High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity.

Nellie Taleux 1, * Bruno Guigas 2 Hervé Dubouchaud 1 Maria Moreno 3 Joachim Weitzel 4 Fernando Goglia 3 Roland Favier 1 Xavier Leverve 1
* Auteur correspondant
1 LBFA - Laboratoire de bioénergétique fondamentale et appliquée
2 Laboratoire de Gastro-entérologie
3 Dipartimento delle Scienze Biologiche
4 Institute of Experimental Endocrinology
Abstract : Besides its well recognized role in lipid and carbohydrate metabolisms, glycerol is involved in the regulation of cellular energy homeostasis via glycerol-3-phosphate, a key metabolite in the translocation of reducing power across the mitochondrial inner membrane with mitochondrial glycerol-3-phosphate dehydrogenase. Here, we report a high rate of gluconeogenesis from glycerol and fatty acid oxidation in hepatocytes from Lou/C, a peculiar rat strain derived from Wistar, which is resistant to age- and diet-related obesity. This feature, associated with elevated cellular respiration and cytosolic ATP/ADP and NAD(+)/NADH ratios, was linked to a high expression and activity of mitochondrial glycerol-3-phosphate dehydrogenase. Interestingly, this strain exhibited high expression and protein content of thyroid hormone receptor, whereas circulating thyroid hormone levels were slightly decreased and hepatic thyroid hormone carrier MCT-8 mRNA levels were not modified. We propose that an enhanced liver thyroid hormone receptor in Lou/C may explain its unique resistance to obesity by increasing fatty acid oxidation and lowering liver oxidative phosphorylation stoichiometry at the translocation of reducing power into mitochondria.
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Article dans une revue
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (7), pp.4308-16. 〈10.1074/jbc.M806187200〉
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Contributeur : Sarah Hamant <>
Soumis le : mardi 26 mai 2009 - 19:37:20
Dernière modification le : mercredi 7 novembre 2018 - 16:07:41

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Nellie Taleux, Bruno Guigas, Hervé Dubouchaud, Maria Moreno, Joachim Weitzel, et al.. High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (7), pp.4308-16. 〈10.1074/jbc.M806187200〉. 〈inserm-00388518〉

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