Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. - Archive ouverte HAL Access content directly
Journal Articles Journal of Investigative Dermatology Year : 2009

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.

(1) , (2) , (3) , (3) , (2) , (3) , (3) , (2) , (2, 4) , (2, 4)
1
2
3
4

Abstract

COUP-TF-interacting protein 2 (CTIP2; also known as Bcl11b) is a transcription factor that plays key roles in the development of the central nervous and immune systems. CTIP2 is also highly expressed in the developing epidermis, and at lower levels in the dermis and in adult skin. Analyses of mice harboring a germline deletion of CTIP2 revealed that the protein plays critical roles in skin during development, particularly in keratinocyte proliferation and late differentiation events, as well as in the development of the epidermal permeability barrier. At the core of all of these actions is a relatively large network of genes, described herein, that is regulated directly or indirectly by CTIP2. The analysis of conditionally null mice, in which expression of CTIP2 was ablated specifically in epidermal keratinocytes, suggests that CTIP2 functions in both cell and non-cell autonomous contexts to exert regulatory influence over multiple phases of skin development, including barrier establishment. Considered together, our results suggest that CTIP2 functions as a top-level regulator of skin morphogenesis.

Dates and versions

inserm-00387992 , version 1 (26-05-2009)

Identifiers

Cite

Olga Golonzhka, Xiaobo Liang, Nadia Messaddeq, Jean-Marc Bornert, Adam L. Campbell, et al.. Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.. Journal of Investigative Dermatology, 2009, 129 (6), pp.1459-70. ⟨10.1038/jid.2008.392⟩. ⟨inserm-00387992⟩
35 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More