Skip to Main content Skip to Navigation
Journal articles

Musclin gene expression is strongly related to fast-glycolytic phenotype.

Abstract : Musclin has been described as a muscle-derived secretory peptide, responsive to insulin in vivo, and inducing insulin resistance in vitro. Because muscle fibers display very different metabolic properties and insulin sensitivity, we tested the hypothesis that musclin expression could depend on myofiber type. Musclin mRNA was detected at high level in fast gastrocnemius and plantaris muscles, but only as traces in soleus, a slow-twitch muscle. A single fiber analysis showed that musclin was produced by muscle fibers themselves, almost exclusively type IIb fibers. Slow to fast transition of soleus phenotype after hindlimb suspension increased musclin mRNA levels, whereas fast to slow transition of plantaris phenotype after functional overload decreased musclin mRNA levels. This clearly suggests that musclin transcription is strongly related to fast-glycolytic phenotype. We conclude that musclin is produced by myocytes in a highly fiber-type specific manner and that physiological changes in type IIb MHC lead to coordinated musclin expression.
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00387969
Contributor : Valérie Sinniger <>
Submitted on : Wednesday, September 9, 2009 - 6:26:34 PM
Last modification on : Wednesday, November 4, 2020 - 3:43:55 PM
Long-term archiving on: : Saturday, November 26, 2016 - 9:13:06 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

SSA | U836

Citation

Sébastien Banzet, Nathalie Koulmann, Hervé Sanchez, Bernard Serrurier, André Peinnequin, et al.. Musclin gene expression is strongly related to fast-glycolytic phenotype.. Biochemical and Biophysical Research Communications, Elsevier, 2007, 353 (3), pp.713-8. ⟨10.1016/j.bbrc.2006.12.074⟩. ⟨inserm-00387969⟩

Share

Metrics

Record views

235