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Gcm protein degradation suppresses proliferation of glial progenitors.

Abstract : Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here we describe the ubiquitin-proteasome regulation of the Gcm protein and the consequence in gliogenesis without timely degradation of Gcm. Gcm binds to 2 F-box proteins, Supernumerary limbs (Slimb) and Archipelago (Ago), adaptors of SCF E3 ubiquitin ligases. Ubiquitination and proteasomal degradation of Gcm depend on slimb and ago. In slimb and ago double mutants, Gcm protein levels are enhanced. Concomitantly, glial cell numbers increase owing to proliferation, which can be phenocopied by Gcm overexpression only at the onset of glial differentiation. The glial lineage 5-6A in slimb ago mutants displays excess glial progenies and enhanced Gcm protein levels. We propose that downregulation of Gcm protein levels by Slimb and Ago is required for glial progenitors to exit the cell cycle for differentiation.
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Submitted on : Tuesday, May 26, 2009 - 9:55:04 AM
Last modification on : Tuesday, May 31, 2022 - 10:20:14 AM

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Margaret Su-Chun Ho, Hungwen Chen, Minghan Chen, Cécile Jacques, Angela Giangrande, et al.. Gcm protein degradation suppresses proliferation of glial progenitors.. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (16), pp.6778-83. ⟨10.1073/pnas.0808899106⟩. ⟨inserm-00387878⟩



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