Skip to Main content Skip to Navigation
Journal articles

Interference of pollutants with PPARs: endocrine disruption meets metabolism.

Abstract : The concept of endocrine disruption emerged over a decade ago with the observation that several natural or industrial compounds can interfere with estrogen and androgen signaling, and thereby affect both male and female reproductive functions. Since then, many endocrine-disrupting chemicals (EDCs) have been identified and the concept has been broadened to receptors regulating other aspects of endocrine pathways. In that context, interference of EDCs with receptors regulating metabolism has been proposed as a factor that could contribute to metabolic diseases such as obesity and diabetes. We review recent studies showing that several pollutants, including phthalates and organotins, interfere with PPAR (peroxisome proliferator-activated receptors) nuclear receptors and may thereby affect metabolic homeostasis. Particular emphasis is given on the mechanisms of action of these compounds. However, unlike what has been suspected, we provide evidence from mouse models suggesting that in utero exposure to the phthalate ester di-ethyl-hexyl-phthalate most likely does not predispose to obesity. Collectively, these studies define a subclass of EDCs that perturb metabolic signaling and that we propose to define as metabolic disruptors.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00384586
Contributor : Maité Peney <>
Submitted on : Tuesday, May 26, 2009 - 4:58:07 PM
Last modification on : Monday, March 9, 2020 - 9:40:02 AM

Links full text

Identifiers

Collections

Citation

Cristina Casals-Casas, Jérôme Feige, Béatrice Desvergne. Interference of pollutants with PPARs: endocrine disruption meets metabolism.. International Journal of Obesity, Nature Publishing Group, 2008, 32 Suppl 6, pp.S53-61. ⟨10.1038/ijo.2008.207⟩. ⟨inserm-00384586⟩

Share

Metrics

Record views

105